BRD4

Information BRD4

Description

The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

Full Name

bromodomain containing 4

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
255
Biotypes
82
Peaks
7,094,864
Non-redundant peaks
1,105,211

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
23476
Official Gene Name
BRD4
JASPAR
Ensembl
ENSG00000141867
UniProt
O60885
Genevisible
O60885
RefSeq
NM_001330384
Aliases
CAP; HUNK1; HUNKI; MCAP
All peaks BRD4
Download BED file
Non redundant peaks BRD4
Download BED file
SEQUENCES BRD4
Download FASTA file
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Datasets Table for BRD4

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
BRD4 LPS141 GEO Homo sapiens GSE111253 20,954
BRD4 MCF-7 parental_4-hydroxytamoxifen GEO Homo sapiens GSE123284 40,341
BRD4 MCF-7 GEO Homo sapiens GSE55921 9,745
BRD4 MCF-7 E2 GEO Homo sapiens GSE55921 9,314
BRD4 MCF-7 ARID1A-KO GEO Homo sapiens GSE123284 30,861
BRD4 MCF-7 parental GEO Homo sapiens GSE123284 34,069
BRD4 KK-1 JQ1 GEO Homo sapiens GSE94732 3,283
BRD4 KK-1 DMSO GEO Homo sapiens GSE94732 4,771
BRD4 BE2C GEO Homo sapiens GSE80151 19,967
BRD4 HFOB DIFF GEO Homo sapiens GSE82295 17,914
BRD4 SGBS GEO Homo sapiens GSE64233 6,093
BRD4 SGBS TNF GEO Homo sapiens GSE64233 8,186
BRD4 HCC1806 100nMtrametinib300nMJQ1_24h GEO Homo sapiens GSE87418 19,678
BRD4 HCC1806 DMSO_24h GEO Homo sapiens GSE87418 16,723
BRD4 HCC1806 100nMtrametinib_24h GEO Homo sapiens GSE87418 30,217
BRD4 HCC1806 300nMJQ1_24h GEO Homo sapiens GSE87418 12,803
BRD4 HCC1806 GEO Homo sapiens GSE124748 7,182
BRD4 HAP1 GEO Homo sapiens GSE108387 19,783
BRD4 HAP1 DMSO GEO Homo sapiens GSE105786 339
BRD4 GM15850 PA1_JQ1 GEO Homo sapiens GSE99402 17,685
BRD4 GM15850 Syn-TEF1 GEO Homo sapiens GSE99402 28,405
BRD4 GM15850 DMSO GEO Homo sapiens GSE99402 25,514
BRD4 HEK293 sgMYOD GEO Homo sapiens GSE129407 2,108
BRD4 HEK293 sgNT GEO Homo sapiens GSE129407 63,239
BRD4 HEK293 Ctrl GEO Homo sapiens GSE129407 45,099
BRD4 SUM159 RES GEO Homo sapiens GSE63581 1,934
BRD4 SUM159 GEO Homo sapiens GSE63581 617
BRD4 SUM149 DMSO GEO Homo sapiens GSE63581 13,794
BRD4 BCBL-1 TREx-F3H3-K-Rt GEO Homo sapiens GSE103395 591
BRD4 MPNST PDJQ GEO Homo sapiens GSE62499 45,081
BRD4 MV4-11 IBET GEO Homo sapiens GSE71776 38,488
BRD4 MV4-11 DMSO GEO Homo sapiens GSE71776 36,781
BRD4 MV4-11 SGC GEO Homo sapiens GSE71776 61,886
BRD4 MV4-11 IBET_SGC GEO Homo sapiens GSE71776 27,603
BRD4 MV4-11 IBET151_50nM GEO Homo sapiens GSE120715 22,252
BRD4 MV4-11 IBET151_500nM GEO Homo sapiens GSE120715 4,855
BRD4 MV4-11 DMSO GEO Homo sapiens GSE120715 40,959
BRD4 MV4-11 IBET151_5000nM GEO Homo sapiens GSE120715 5,085
BRD4 22Rv1 DHT-ABBV-744 GEO Homo sapiens GSE118247 19,143
BRD4 22Rv1 DHT-DMSO GEO Homo sapiens GSE118247 28,186
BRD4 22Rv1 DHT-ABBV-075 GEO Homo sapiens GSE118247 14,127
BRD4 MOLT-4 DMSO GEO Homo sapiens GSE79288 15,705
BRD4 Mutu-1 vehicle GEO Homo sapiens GSE84213 27,035
BRD4 Mutu-1 JQ1 GEO Homo sapiens GSE84213 8,909
BRD4 SUM185 DMSO GEO Homo sapiens GSE63581 16,131
BRD4 HEK293T GEO Homo sapiens GSE39579 14,072
BRD4 HEK293T GEO Homo sapiens GSE51633 26,645
BRD4 HCC1395 GEO Homo sapiens GSE63581 61,647
BRD4 HCC1395 JQ1 GEO Homo sapiens GSE63581 30,055
BRD4 IMR-90 QUIES GEO Homo sapiens GSE74238 73,691
BRD4 IMR-90 PROLIF GEO Homo sapiens GSE74238 620
BRD4 IMR-90 SENES GEO Homo sapiens GSE74238 27,034
BRD4 LP1 CPI203 GEO Homo sapiens GSE71909 181
BRD4 LP1 SGCCBP300 GEO Homo sapiens GSE71909 644
BRD4 LP1 GEO Homo sapiens GSE71909 1,231
BRD4 OCI-Ly1 JQ1 GEO Homo sapiens GSE53601 13,503
BRD4 OCI-Ly1 DMSO GEO Homo sapiens GSE53601 5,550
BRD4 VCaP R1881 GEO Homo sapiens GSE148358 26,076
BRD4 VCaP Darolutamide GEO Homo sapiens GSE148358 24,552
BRD4 VCaP GEO Homo sapiens GSE148358 35,983
BRD4 THP-1 DMSO GEO Homo sapiens GSE138084 39,107
BRD4 THP-1 DMSO-PMA GEO Homo sapiens GSE138084 29,862
BRD4 THP-1 iBET-BD1-PMA GEO Homo sapiens GSE138084 30,930
BRD4 THP-1 iBET-BD1 GEO Homo sapiens GSE138084 21,110
BRD4 THP-1 iBET-BD2-PMA GEO Homo sapiens GSE138084 20,172
BRD4 THP-1 iBET GEO Homo sapiens GSE138084 20,653
BRD4 THP-1 iBET-BD2 GEO Homo sapiens GSE138084 48,206
BRD4 PC-3 GDC-R_SAHA GEO Homo sapiens GSE137207 42,538
BRD4 PC-3 GDC-R GEO Homo sapiens GSE137207 38,829
BRD4 PC-3 GEO Homo sapiens GSE137207 17,872
BRD4 MOLM-14 IBET GEO Homo sapiens GSE65138 38,872
BRD4 MOLM-14 DMSO GEO Homo sapiens GSE65138 35,729
BRD4 MOLM-14 CA25 GEO Homo sapiens GSE65138 24,113
BRD4 OVCAR-3 DMSO GEO Homo sapiens GSE77568 13,722
BRD4 OVCAR-3 JQ1 GEO Homo sapiens GSE77568 370
BRD4 MDA-MB-436 DMSO GEO Homo sapiens GSE63581 6,116
BRD4 Jurkat GEO Homo sapiens GSE83777 46,274
BRD4 MCF-10A ENA Homo sapiens ERP003925 38,265
BRD4 T-47D DMSO GEO Homo sapiens GSE63581 24,473
BRD4 T-47D ENA Homo sapiens ERP003925 21,141
BRD4 HCC1937 GEO Homo sapiens GSE124748 29,546
BRD4 SUM149PT DMSO GEO Homo sapiens GSE131097 8,833
BRD4 402-91 GEO Homo sapiens GSE111253 19,872
BRD4 SEM GEO Homo sapiens GSE83671 32,988
BRD4 RH4 GEO Homo sapiens GSE83726 16,399
BRD4 RH4 shCHD4 GEO Homo sapiens GSE140115 54,319
BRD4 RH4 shscr GEO Homo sapiens GSE140115 41,422
BRD4 BT-474 INHHDAC ENA Homo sapiens ERP010664 3,783
BRD4 BT-474 ENA Homo sapiens ERP010664 6,422
BRD4 HeLa GEO Homo sapiens GSE51633 17,143
BRD4 HeLa GEO Homo sapiens GSE151038 35,983
BRD4 HeLa JQ1 GEO Homo sapiens GSE151038 48,238
BRD4 HT29 GEO Homo sapiens GSE73319 26,751
BRD4 Hep-G2 CEBPB-enh-neg GEO Homo sapiens GSE123097 2,025
BRD4 Hep-G2 GEO Homo sapiens GSE123097 12,258
BRD4 KOPT-K1 E GEO Homo sapiens GSE54379 34,455
BRD4 KOPT-K1 GEO Homo sapiens GSE54379 35,852
BRD4 NCI-H2171 GEO Homo sapiens GSE101821 5,621
BRD4 NCI-H2171 DMSO GEO Homo sapiens GSE49224 6,120
BRD4 K-562 JQ1_6h GEO Homo sapiens GSE99178 15,041
BRD4 K-562 DMSO GEO Homo sapiens GSE99178 34,378
BRD4 K-562 JQ1_2h GEO Homo sapiens GSE99178 21,843
BRD4 K-562 iBET-IFNG GEO Homo sapiens GSE138084 46,541
BRD4 K-562 GEO Homo sapiens GSE140325 14,683
BRD4 K-562 IBET151_5000nM GEO Homo sapiens GSE120715 314
BRD4 K-562 iBET-BD1-IFNG GEO Homo sapiens GSE138084 48,079
BRD4 K-562 dilution-6-100 GEO Homo sapiens GSE140325 21,194
BRD4 K-562 iBET GEO Homo sapiens GSE138084 24,753
BRD4 K-562 iBET-BD1 GEO Homo sapiens GSE138084 11,888
BRD4 K-562 iBET-BD2 GEO Homo sapiens GSE138084 33,583
BRD4 K-562 IBET151_50nM GEO Homo sapiens GSE120715 5,424
BRD4 K-562 IBET151_500nM GEO Homo sapiens GSE120715 260
BRD4 K-562 DMSO GEO Homo sapiens GSE138084 42,368
BRD4 K-562 DMSO-IFNG GEO Homo sapiens GSE138084 41,806
BRD4 K-562 DMSO GEO Homo sapiens GSE120715 8,677
BRD4 K-562 iBET-BD2-IFNG GEO Homo sapiens GSE138084 55,601
BRD4 CLB-Ga Dinaciclib GEO Homo sapiens GSE133453 2,550
BRD4 CLB-Ga GEO Homo sapiens GSE133453 1,840
BRD4 NCI-H1963 shASXL3 GEO Homo sapiens GSE145028 27,149
BRD4 NCI-H1963 GEO Homo sapiens GSE145028 31,003
BRD4 NCI-H1963 shNONT GEO Homo sapiens GSE145028 29,650
BRD4 NCI-H1963 dBET6 GEO Homo sapiens GSE145028 21,445
BRD4 MDA-MB-231 ENA Homo sapiens ERP003925 6,943
BRD4 MDA-MB-231 DMSO_rDNA GEO Homo sapiens GSE116879 44,822
BRD4 MDA-MB-231 JQ1-neg_S_3f GEO Homo sapiens GSE136151 28,614
BRD4 MDA-MB-231 JQ1 GEO Homo sapiens GSE116879 43,491
BRD4 MDA-MB-231 MGSK2801 GEO Homo sapiens GSE116879 75,346
BRD4 MDA-MB-231 JQ1-pos_L GEO Homo sapiens GSE136151 12,498
BRD4 MDA-MB-231 MGSK2801_rDNA GEO Homo sapiens GSE116879 75,362
BRD4 MDA-MB-231 JQ1_rDNA GEO Homo sapiens GSE116879 43,497
BRD4 MDA-MB-231 JQ1_MGSK2801_rDNA GEO Homo sapiens GSE116879 62,204
BRD4 MDA-MB-231 JQ1_MGSK2801 GEO Homo sapiens GSE116879 62,173
BRD4 MDA-MB-231 DMSO GEO Homo sapiens GSE116879 44,777
BRD4 MDA-MB-231 JQ1-neg_L GEO Homo sapiens GSE136151 28,805
BRD4 K-562 ENCODE Homo sapiens ENCSR583ACG 8,929
BRD4 Hep-G2 ENCODE Homo sapiens ENCSR514EOE 7,181
BRD4 HUVEC-C MS417 GEO Homo sapiens GSE60171 84
BRD4 HUVEC-C GEO Homo sapiens GSE53998 20,533
BRD4 HUVEC-C TNF_JQ1 GEO Homo sapiens GSE53998 6,254
BRD4 HUVEC-C modETS1 GEO Homo sapiens GSE93030 16,366
BRD4 HUVEC-C TNF GEO Homo sapiens GSE53998 21,508
BRD4 HUVEC-C GEO Homo sapiens GSE60171 4,084
BRD4 HUVEC-C modGFP GEO Homo sapiens GSE93030 13,508
BRD4 CHL-1 BAY123897 GEO Homo sapiens GSE95585 7,085
BRD4 CHL-1 OTX015 GEO Homo sapiens GSE95585 5,674
BRD4 CHL-1 GEO Homo sapiens GSE95585 30,674
BRD4 keratinocyte GEO Homo sapiens GSE140992 28,207
BRD4 MCF-7 ARID1A-KO_4-OHT GEO Homo sapiens GSE123284 34,475
BRD4 SUM159PT DMSO GEO Homo sapiens GSE131097 10,237
BRD4 SUM159PT KO GEO Homo sapiens GSE131097 45,716
BRD4 SUM159PT scramble GEO Homo sapiens GSE131097 53,927
BRD4 SUM159PT DMSO_72h GEO Homo sapiens GSE87418 37,315
BRD4 SUM159PT shMYC_dox_48h GEO Homo sapiens GSE87418 66,007
BRD4 SUM159PT shMYC_DMSO_48h GEO Homo sapiens GSE87418 53,218
BRD4 SUM159PT Dox_48h GEO Homo sapiens GSE87418 51,767
BRD4 SUM159PT DMSO_8h GEO Homo sapiens GSE87418 56,863
BRD4 SUM159PT DMSO_24h GEO Homo sapiens GSE87418 55,110
BRD4 SUM159PT DMSO_48h GEO Homo sapiens GSE87418 48,950
BRD4 SUM159PT 100nMtrametinib300nMJQ1_24h GEO Homo sapiens GSE87418 36,921
BRD4 SUM159PT 100nMtrametinib_1h GEO Homo sapiens GSE87418 60,907
BRD4 SUM159PT 300nMJQ1_24h GEO Homo sapiens GSE87418 23,512
BRD4 SUM159PT 30nMbortezomib_8h GEO Homo sapiens GSE87418 79,401
BRD4 SUM159PT 100nMtrametinib_72h GEO Homo sapiens GSE87418 75,877
BRD4 SUM159PT 100nMtrametinib_24h GEO Homo sapiens GSE87418 77,716
BRD4 SUM159PT 100nMtrametinib_8h GEO Homo sapiens GSE87418 62,124
BRD4 SUM159PT 100nMtrametinib_4h GEO Homo sapiens GSE87418 54,962
BRD4 MDA-MB-157 ENA Homo sapiens ERP003925 21,175
BRD4 Kelly sensitive GEO Homo sapiens GSE103030 64,486
BRD4 Kelly resistant GEO Homo sapiens GSE103030 44,971
BRD4 Kelly resistant_JQ1 GEO Homo sapiens GSE103030 23,222
BRD4 SUM229PE pos_DMSO_24h GEO Homo sapiens GSE87418 29,107
BRD4 SUM229PE neg_DMSO_24h GEO Homo sapiens GSE87418 27,033
BRD4 SUM229PE pos_30nMtrametinib_24h GEO Homo sapiens GSE87418 20,809
BRD4 SUM229PE neg_30nMtrametinib_24h GEO Homo sapiens GSE87418 33,494
BRD4 SUM1315 DMSO GEO Homo sapiens GSE63581 23,770
BRD4 CD4 Th1_BAY GEO Homo sapiens GSE62482 19,285
BRD4 CD4 Th1_DMSO GEO Homo sapiens GSE62482 35,350
BRD4 CD4 JG1 GEO Homo sapiens GSE33281 72,198
BRD4 hESC GEO Homo sapiens GSE33281 63,822
BRD4 SW480 16h_TNF-a GEO Homo sapiens GSE110473 33,979
BRD4 SW480 GEO Homo sapiens GSE110473 38,767
BRD4 SW480 GEO Homo sapiens GSE73319 23,745
BRD4 DND41 E GEO Homo sapiens GSE54379 22,587
BRD4 DND41 GEO Homo sapiens GSE54379 10,664
BRD4 P493-6 MYC_0H GEO Homo sapiens GSE42262 3,903
BRD4 P493-6 MYC_24H GEO Homo sapiens GSE42262 1,984
BRD4 P493-6 MYC_1H GEO Homo sapiens GSE42262 8,135
BRD4 COLO-320 GEO Homo sapiens GSE73319 9,104
BRD4 MM1-S JQ1_5NM GEO Homo sapiens GSE42355 57,008
BRD4 MM1-S JQ1 GEO Homo sapiens GSE42161 688
BRD4 MM1-S JQ1_50NM GEO Homo sapiens GSE42355 50,011
BRD4 MM1-S JQ1_5UM GEO Homo sapiens GSE42355 36,935
BRD4 Hs-352-Sk GEO Homo sapiens GSE83725 4,309
BRD4 MM1-S GEO Homo sapiens GSE45984 24,988
BRD4 MM1-S JQ1_500NM GEO Homo sapiens GSE42355 41,653
BRD4 MM1-S JQ1_150NM GEO Homo sapiens GSE49224 42,735
BRD4 MM1-S DMSO GEO Homo sapiens GSE42161 26,379
BRD4 MM1-S GEO Homo sapiens GSE43743 44,659
BRD4 Hs-352-Sk PAX3-FOXO1-vector GEO Homo sapiens GSE83725 14,524
BRD4 T-cell DMSO GEO Homo sapiens GSE138084 34,138
BRD4 T-cell iBET-BD1 GEO Homo sapiens GSE138084 23,192
BRD4 T-cell iBET-BD2 GEO Homo sapiens GSE138084 18,459
BRD4 T-cell iBET GEO Homo sapiens GSE138084 36,400
BRD4 LREX GEO Homo sapiens GSE103449 168
BRD4 LNCaP-C4-2 EV GEO Homo sapiens GSE88871 5,941
BRD4 LNCaP-C4-2 EV_JQ1 GEO Homo sapiens GSE88871 342
BRD4 LNCaP-C4-2 F133V_JQ1 GEO Homo sapiens GSE88871 45,270
BRD4 LNCaP-C4-2 F133V GEO Homo sapiens GSE88871 78,365
BRD4 LNCaP-C4-2 OE GEO Homo sapiens GSE88871 70,083
BRD4 thyroid-cancer GEO Homo sapiens GSE114068 3,491
BRD4 HCT-15 GEO Homo sapiens GSE73319 29,808
BRD4 HCT-116 GEO Homo sapiens GSE57628 12,870
BRD4 HCT-116 JQ1 GEO Homo sapiens GSE57628 3,017
BRD4 HCT-116 GEO Homo sapiens GSE73319 6,674
BRD4 COLO-205 GEO Homo sapiens GSE73319 28,810
BRD4 COLO-741 GEO Homo sapiens GSE73319 55,032
BRD4 OCI-AML3 JQ1_500nM_24h GEO Homo sapiens GSE104745 1,546
BRD4 OCI-AML3 GEO Homo sapiens GSE104745 15,924
BRD4 cortical-interneuron R133C_KCl-pos_JQ1-pos GEO Homo sapiens GSE117508 17,442
BRD4 cortical-interneuron R133C_KCl-neg_JQ1-neg GEO Homo sapiens GSE117508 44,863
BRD4 cortical-interneuron R133C_KCl-neg_JQ1-pos GEO Homo sapiens GSE117508 19,723
BRD4 cortical-interneuron GEO Homo sapiens GSE117508 25,332
BRD4 cortical-interneuron KCl-pos_JQ1-neg GEO Homo sapiens GSE117508 15,326
BRD4 cortical-interneuron KCl-pos GEO Homo sapiens GSE117508 25,172
BRD4 cortical-interneuron R133C_KCl-pos_JQ1-neg GEO Homo sapiens GSE117508 49,089
BRD4 SK-N-BE2-C GEO Homo sapiens GSE80151 20,445
BRD4 SK-N-BE2-C Resistant-veh GEO Homo sapiens GSE107706 36,523
BRD4 SK-N-BE2-C Naive-veh GEO Homo sapiens GSE107706 51,469
BRD4 LNAR Enz GEO Homo sapiens GSE103449 493
BRD4 GEN2-2 GEO Homo sapiens GSE76147 339
BRD4 MV4-11-B BI00894999_100nM_4h GEO Homo sapiens GSE101821 64,274
BRD4 MV4-11-B BI00894999_35nM_4h GEO Homo sapiens GSE101821 68,167
BRD4 MV4-11-B DMSO GEO Homo sapiens GSE101821 47,817
BRD4 LNCaP-clone-FGC DHT-ABBV-744 GEO Homo sapiens GSE118247 11,420
BRD4 LNCaP-clone-FGC DHT-DMSO GEO Homo sapiens GSE118247 20,694
BRD4 LNCaP-clone-FGC DHT-ABBV-075 GEO Homo sapiens GSE118247 15,260
BRD4 LNCaP-clone-FGC DHT-Enzalutamide GEO Homo sapiens GSE118247 23,007
BRD4 CLL patient4_4h_CpG_BET GEO Homo sapiens GSE109411 21,152
BRD4 CLL patient2_4h_CpG GEO Homo sapiens GSE109411 26,512
BRD4 CLL patient4 GEO Homo sapiens GSE109411 32,444
BRD4 CLL patient1 GEO Homo sapiens GSE109411 31,763
BRD4 CLL patient3 GEO Homo sapiens GSE109411 32,776
BRD4 CLL patient2 GEO Homo sapiens GSE109411 49,337
BRD4 CLL patient3_4h_CpG GEO Homo sapiens GSE109411 41,559
BRD4 CLL patient3_4h_CpG_BET GEO Homo sapiens GSE109411 23,763
BRD4 CLL patient4_4h_CpG GEO Homo sapiens GSE109411 29,055
BRD4 CLL patient1_4h_CpG GEO Homo sapiens GSE109411 32,308
BRD4 CLL patient1_4h_CpG_BET GEO Homo sapiens GSE109411 18,768
BRD4 CLL patient2_4h_CpG_BET GEO Homo sapiens GSE109411 34,990
BRD4 NMC24335 GEO Homo sapiens GSE96775 18,175
BRD4 retina AB1-RB GEO Homo sapiens GSE86981 69,679
BRD4 retina AB1-FW15 GEO Homo sapiens GSE86981 74,755
BRD4 retina AB1-FW13 GEO Homo sapiens GSE86981 12,800
BRD4 retina AB1-FW20 GEO Homo sapiens GSE86981 28,664
BRD4 retina AB1-FW23 GEO Homo sapiens GSE86981 29,503
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks