MBD3

Information MBD3

Description

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Full Name

methyl-CpG binding domain protein 3

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
2
Biotypes
2
Peaks
27,102
Non-redundant peaks
26,799

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
53615
Official Gene Name
MBD3
JASPAR
Ensembl
ENSG00000071655
UniProt
O95983
Genevisible
O95983
RefSeq
NM_001281453
Aliases
All peaks MBD3
Download BED file
Non redundant peaks MBD3
Download BED file
SEQUENCES MBD3
Download FASTA file
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Datasets Table for MBD3

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
MBD3 MCF-7 GEO Homo sapiens GSE44737 19,716
MBD3 HEK293T GEO Homo sapiens GSE102945 7,386
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks