MECOM
Information MECOM
- Description
The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
- Full Name
MDS1 and EVI1 complex locus
Source NCBI
- Species
Homo sapiens [tax_id: 9606]
- Genome
hg38
ReMap Statistics
- Datasets
- 7
- Biotypes
- 1
- Peaks
- 87,925
- Non-redundant peaks
- 52,577
TF Classification
- Super Class
- NA
- Class
- NA
- Familly
- NA
- Sub Familly
- NA
Source TFClass
External IDs
- NCBI Gene
- 2122
- Official Gene Name
- MECOM
- JASPAR
- Ensembl
- ENSG00000085276
- UniProt
- Q03112
- Genevisible
- Q03112
- RefSeq
- NM_001105077
- Aliases
- AML1-EVI-1; EVI1; KMT8E; MDS1; MDS1-EVI1; PRDM3; RUSAT2
Datasets Table for MECOM
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| MECOM | SKH1 | CEBPA-ER_E2 | GEO | Homo sapiens | GSE102697 | 24,980 | ||
| MECOM | SKH1 | E2 | GEO | Homo sapiens | GSE102697 | 19,392 | ||
| MECOM | SKH1 | CEBPA-ER | GEO | Homo sapiens | GSE102697 | 28,334 | ||
| MECOM | SKH1 | GEO | Homo sapiens | GSE102697 | 15,219 | |||
| MECOM | SKH1 | RUNX1-EVI1_KD | GEO | Homo sapiens | GSE87283 | 5,660 | ||
| MECOM | SKH1 | GEO | Homo sapiens | GSE87283 | 34,467 | |||
| MECOM | SKH1 | 10d | GEO | Homo sapiens | GSE87283 | 24,164 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |