NOTCH3

Information NOTCH3

Description

This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008]

Full Name

notch receptor 3

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
2
Biotypes
1
Peaks
24,094
Non-redundant peaks
23,525

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
4854
Official Gene Name
NOTCH3
JASPAR
Ensembl
ENSG00000074181
UniProt
Q9UM47
Genevisible
Q9UM47
RefSeq
NM_000435
Aliases
CADASIL; CADASIL1; CASIL; IMF2; LMNS
All peaks NOTCH3
Download BED file
Non redundant peaks NOTCH3
Download BED file
SEQUENCES NOTCH3
Download FASTA file
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Datasets Table for NOTCH3

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
NOTCH3 TALL-1 DMSO GEO Homo sapiens GSE104261 6,732
NOTCH3 TALL-1 GSI GEO Homo sapiens GSE104261 17,362
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks