SMC1A

Information SMC1A

Description

Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

Full Name

structural maintenance of chromosomes 1A

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
26
Biotypes
13
Peaks
543,090
Non-redundant peaks
183,337

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
8243
Official Gene Name
SMC1A
JASPAR
Ensembl
ENSG00000072501
UniProt
Q14683
Genevisible
Q14683
RefSeq
NM_001281463
Aliases
CDLS2; DXS423E; KIAA0178; SB1.8; SMC1; SMC1L1; SMC1alpha; SMCB
All peaks SMC1A
Download BED file
Non redundant peaks SMC1A
Download BED file
SEQUENCES SMC1A
Download FASTA file
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Datasets Table for SMC1A

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
SMC1A MCF-7 GEO Homo sapiens GSE115602 36,614
SMC1A MCF-7 EtOH GEO Homo sapiens GSE115602 51,938
SMC1A A-549 GEO Homo sapiens GSE76893 62,872
SMC1A monocyte INFg GEO Homo sapiens GSE98367 71,899
SMC1A LCL GEO Homo sapiens GSE38395 18,547
SMC1A Hep-G2 GEO Homo sapiens GSE76893 65,887
SMC1A MCF-7 GEO Homo sapiens GSE76893 43,086
SMC1A IMR-90 OIS GEO Homo sapiens GSE118494 25,582
SMC1A IMR-90 G GEO Homo sapiens GSE118494 24,538
SMC1A monocyte IFNg-LPS GEO Homo sapiens GSE120943 56,988
SMC1A MCF-10A GEO Homo sapiens GSE101921 26,179
SMC1A HMEC-1 GEO Homo sapiens GSE101921 24,946
SMC1A HAP1 SCC4KO GEO Homo sapiens GSE94992 5,853
SMC1A HAP1 WaplKO-33_SCC4KO GEO Homo sapiens GSE94992 28,211
SMC1A HAP1 GEO Homo sapiens GSE94992 18,395
SMC1A HAP1 WaplKO-33 GEO Homo sapiens GSE94992 38,849
SMC1A DKO GEO Homo sapiens GSE131606 71,662
SMC1A HCT-116 GEO Homo sapiens GSE112000 13,751
SMC1A HCT-116 RAD21-mAC_500uM_auxin GEO Homo sapiens GSE104888 7,079
SMC1A HCT-116 RAD21-mAC GEO Homo sapiens GSE104888 41,373
SMC1A HCT-116 GEO Homo sapiens GSE131606 49,050
SMC1A HCAEC GEO Homo sapiens GSE101921 72,109
SMC1A primary-epidermal-keratinocyte GEO Homo sapiens GSE85526 54,371
SMC1A primary-epidermal-keratinocyte diff_d0 GEO Homo sapiens GSE84657 34,672
SMC1A primary-epidermal-keratinocyte diff_d3 GEO Homo sapiens GSE84657 43,281
SMC1A primary-epidermal-keratinocyte diff_d6 GEO Homo sapiens GSE84657 46,172
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks