TLE3
Information TLE3
- Description
This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]
- Full Name
TLE family member 3, transcriptional corepressor
Source NCBI
- Species
Homo sapiens [tax_id: 9606]
- Genome
hg38
ReMap Statistics
- Datasets
- 10
- Biotypes
- 5
- Peaks
- 180,504
- Non-redundant peaks
- 96,525
TF Classification
- Super Class
- NA
- Class
- NA
- Familly
- NA
- Sub Familly
- NA
Source TFClass
External IDs
- NCBI Gene
- 7090
- Official Gene Name
- TLE3
- JASPAR
- Ensembl
- ENSG00000140332
- UniProt
- Q04726
- Genevisible
- Q04726
- RefSeq
- NM_001105192
- Aliases
- ESG; ESG3; GRG3; HsT18976; KIAA1547
Datasets Table for TLE3
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| TLE3 | MCF-7 | GEO | Homo sapiens | GSE41561 | 7,873 | |||
| TLE3 | LAPC-4 | TFS | GEO | Homo sapiens | GSE123618 | 2,550 | ||
| TLE3 | 22Rv1 | Crispr-36 | GEO | Homo sapiens | GSE123618 | 2,085 | ||
| TLE3 | 22Rv1 | Crispr-57 | GEO | Homo sapiens | GSE123618 | 1,402 | ||
| TLE3 | 22Rv1 | WT3_Crispr | GEO | Homo sapiens | GSE123618 | 14,063 | ||
| TLE3 | 22Rv1 | GEO | Homo sapiens | GSE123618 | 13,437 | |||
| TLE3 | LNCaP | GEO | Homo sapiens | GSE94682 | 70,329 | |||
| TLE3 | LNCaP | r1881 | GEO | Homo sapiens | GSE94682 | 61,504 | ||
| TLE3 | LNCaP | GEO | Homo sapiens | GSE123618 | 2,988 | |||
| TLE3 | LNCaP-C4-2B | GEO | Homo sapiens | GSE123618 | 4,273 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |