WRNIP1

Information WRNIP1

Description

Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012]

Full Name

WRN helicase interacting protein 1

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
1
Biotypes
1
Peaks
67
Non-redundant peaks
67

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
56897
Official Gene Name
WRNIP1
JASPAR
Ensembl
ENSG00000124535
UniProt
Q96S55
Genevisible
Q96S55
RefSeq
NM_020135
Aliases
FLJ22526; WHIP; bA420G6.2
All peaks WRNIP1
Download BED file
Non redundant peaks WRNIP1
Download BED file
SEQUENCES WRNIP1
Download FASTA file
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Datasets Table for WRNIP1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
WRNIP1 GM12878 ENCODE Homo sapiens ENCSR000EAA 67
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks