WT1

Information WT1

Description

This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015]

Full Name

WT1 transcription factor

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
1
Biotypes
1
Peaks
39,677
Non-redundant peaks
39,677

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
7490
Official Gene Name
WT1
JASPAR
Ensembl
ENSG00000184937
UniProt
P19544
Genevisible
P19544
RefSeq
NM_000378
Aliases
AWT1; GUD; NPHS4; WAGR; WIT-2; WT33
All peaks WT1
Download BED file
Non redundant peaks WT1
Download BED file
SEQUENCES WT1
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for WT1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
WT1 HEK293 ENCODE Homo sapiens ENCSR966PJJ 39,677
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks