AGO1

Information AGO1

Description

This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon. [provided by RefSeq, Nov 2015]

Full Name

argonaute RISC component 1

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
4
Biotypes
2
Peaks
149,218
Non-redundant peaks
77,244

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
26523
Official Gene Name
AGO1
JASPAR
Ensembl
ENSG00000092847
UniProt
Q9UL18
Genevisible
Q9UL18
RefSeq
NM_001317122
Aliases
EIF2C; EIF2C1; GERP95; Q99; hAGO1; hAgo1
All peaks AGO1
Download BED file
Non redundant peaks AGO1
Download BED file
SEQUENCES AGO1
Download FASTA file
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Datasets Table for AGO1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
AGO1 Hep-G2 GEO Homo sapiens GSE120104 51,141
AGO1 K-562 GEO Homo sapiens GSE120104 16,182
AGO1 K-562 ENCODE Homo sapiens ENCSR641BSL 22,730
AGO1 Hep-G2 ENCODE Homo sapiens ENCSR555ZMV 59,165
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks