ASCL1

Information ASCL1

Description

This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. [provided by RefSeq, Jul 2008]

Full Name

achaete-scute family bHLH transcription factor 1

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
8
Biotypes
6
Peaks
129,062
Non-redundant peaks
73,171

TF Classification

Super Class
Basic domains
Class
Basic helix-loop-helix factors (bHLH)
Familly
MyoD / ASC-related factors
Sub Familly
Achaete-Scute-like factors

Source TFClass

External IDs

NCBI Gene
429
Official Gene Name
ASCL1
JASPAR
MA1100
Ensembl
ENSG00000139352
UniProt
P50553
Genevisible
P50553
RefSeq
NM_004316
Aliases
ASH1; HASH1; MASH1; bHLHa46
All peaks ASCL1
Download BED file
Non redundant peaks ASCL1
Download BED file
SEQUENCES ASCL1
Download FASTA file
DOWNLOAD All ReMap
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Datasets Table for ASCL1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
ASCL1 NCI-H128 GEO Homo sapiens GSE69394 6,059
ASCL1 SCLC ASCLP GEO Homo sapiens GSE61197 31,037
ASCL1 SCLC ASCLM GEO Homo sapiens GSE61197 203
ASCL1 SCLC ASCLP_NE GEO Homo sapiens GSE61197 9,833
ASCL1 NCI-H889 GEO Homo sapiens GSE69394 31,933
ASCL1 NCI-H82 GEO Homo sapiens GSE69394 26,104
ASCL1 NCI-H2107 GEO Homo sapiens GSE69394 22,340
ASCL1 G523NS Dox GEO Homo sapiens GSE87618 1,553
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks