ASXL1

Information ASXL1

Description

This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

Full Name

ASXL transcriptional regulator 1

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
1
Biotypes
1
Peaks
9,355
Non-redundant peaks
9,355

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
171023
Official Gene Name
ASXL1
JASPAR
Ensembl
ENSG00000171456
UniProt
Q8IXJ9
Genevisible
Q8IXJ9
RefSeq
NM_001164603
Aliases
KIAA0978
All peaks ASXL1
Download BED file
Non redundant peaks ASXL1
Download BED file
SEQUENCES ASXL1
Download FASTA file
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Datasets Table for ASXL1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
ASXL1 HEK293T GEO Homo sapiens GSE51673 9,355
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks