ATF1

Information ATF1

Description

This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010]

Full Name

activating transcription factor 1

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
5
Biotypes
3
Peaks
67,951
Non-redundant peaks
51,435

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
466
Official Gene Name
ATF1
JASPAR
Ensembl
ENSG00000123268
UniProt
P18846
Genevisible
P18846
RefSeq
NM_005171
Aliases
EWS-ATF1; FUS/ATF-1; TREB36
All peaks ATF1
Download BED file
Non redundant peaks ATF1
Download BED file
SEQUENCES ATF1
Download FASTA file
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Datasets Table for ATF1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
ATF1 K-562 ENCODE Homo sapiens ENCSR000DNZ 9,811
ATF1 K-562 ENCODE Homo sapiens ENCSR091GVJ 39,405
ATF1 K-562 ENCODE Homo sapiens ENCSR159OCC 3,544
ATF1 Hep-G2 ENCODE Homo sapiens ENCSR253OON 2,278
ATF1 HCT-116 GEO Homo sapiens GSE130477 12,913
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks