ATRX

Information ATRX

Description

The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2017]

Full Name

ATRX chromatin remodeler

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
6
Biotypes
4
Peaks
82,876
Non-redundant peaks
62,885

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
546
Official Gene Name
ATRX
JASPAR
Ensembl
ENSG00000085224
UniProt
P46100
Genevisible
P46100
RefSeq
NM_000489
Aliases
JMS; MRX52; RAD54; RAD54L; XH2; XNP; ZNF-HX
All peaks ATRX
Download BED file
Non redundant peaks ATRX
Download BED file
SEQUENCES ATRX
Download FASTA file
DOWNLOAD All ReMap
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Datasets Table for ATRX

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
ATRX erythroid GEO Homo sapiens GSE22162 1,280
ATRX K-562 KOATRX GEO Homo sapiens GSE70920 189
ATRX LA-N-6 KOATRX GEO Homo sapiens GSE70920 208
ATRX metastatic-neuroblastoma SKNFI GEO Homo sapiens GSE100148 18,911
ATRX metastatic-neuroblastoma CHLA90 GEO Homo sapiens GSE100148 34,348
ATRX metastatic-neuroblastoma SKNMM GEO Homo sapiens GSE100148 27,940
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks