CBFB

Information CBFB

Description

The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Full Name

core-binding factor subunit beta

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
6
Biotypes
5
Peaks
169,361
Non-redundant peaks
122,366

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
865
Official Gene Name
CBFB
JASPAR
Ensembl
ENSG00000067955
UniProt
Q13951
Genevisible
Q13951
RefSeq
NM_001368707
Aliases
PEBP2B
All peaks CBFB
Download BED file
Non redundant peaks CBFB
Download BED file
SEQUENCES CBFB
Download FASTA file
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Datasets Table for CBFB

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
CBFB SKNO-1 GEO Homo sapiens GSE23730 17,247
CBFB SaOS-2 GEO Homo sapiens GSE76937 11,841
CBFB ME-1 GEO Homo sapiens GSE46044 54,183
CBFB ME-1 GEO Homo sapiens GSE117138 2,242
CBFB Hep-G2 ENCODE Homo sapiens ENCSR479RZV 50,738
CBFB GM12878 ENCODE Homo sapiens ENCSR860UHK 33,110
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks