CDK6

Information CDK6

Description

The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. [provided by RefSeq, Aug 2017]

Full Name

cyclin dependent kinase 6

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
2
Biotypes
1
Peaks
72,132
Non-redundant peaks
68,497

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
1021
Official Gene Name
CDK6
JASPAR
Ensembl
ENSG00000105810
UniProt
Q00534
Genevisible
Q00534
RefSeq
NM_001145306
Aliases
MCPH12; PLSTIRE
All peaks CDK6
Download BED file
Non redundant peaks CDK6
Download BED file
SEQUENCES CDK6
Download FASTA file
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Datasets Table for CDK6

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
CDK6 KB IL GEO Homo sapiens GSE52469 61,461
CDK6 KB GEO Homo sapiens GSE52469 10,671
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks