CLOCK

Information CLOCK

Description

The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Full Name

clock circadian regulator

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
15
Biotypes
6
Peaks
92,656
Non-redundant peaks
82,106

TF Classification

Super Class
Basic domains
Class
Basic helix-loop-helix factors (bHLH)
Familly
PAS domain factors
Sub Familly
Arnt-like factors

Source TFClass

External IDs

NCBI Gene
9575
Official Gene Name
CLOCK
JASPAR
MA0819
Ensembl
ENSG00000134852
UniProt
O15516
Genevisible
O15516
RefSeq
NM_001267843
Aliases
KAT13D; KIAA0334; bHLHe8
All peaks CLOCK
Download BED file
Non redundant peaks CLOCK
Download BED file
SEQUENCES CLOCK
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for CLOCK

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
CLOCK K-562 ENCODE Homo sapiens ENCSR228OQM 542
CLOCK neural progenitor-O62409 GEO Homo sapiens GSE96659 408
CLOCK MCF-7 ENCODE Homo sapiens ENCSR934JDG 9,890
CLOCK MCF-7 ENCODE Homo sapiens ENCSR699YFX 10,847
CLOCK U2OS GEO Homo sapiens GSE44236 24,359
CLOCK BA40 3 GEO Homo sapiens GSE96659 14,295
CLOCK BA40 2 GEO Homo sapiens GSE96659 1,076
CLOCK BA40 1 GEO Homo sapiens GSE96659 981
CLOCK BA40 0 GEO Homo sapiens GSE96659 11,399
CLOCK BA40 4 GEO Homo sapiens GSE96659 1,763
CLOCK BA10 0 GEO Homo sapiens GSE96659 667
CLOCK BA10 2 GEO Homo sapiens GSE96659 11,458
CLOCK BA10 3 GEO Homo sapiens GSE96659 1,107
CLOCK BA10 4 GEO Homo sapiens GSE96659 2,027
CLOCK BA10 1 GEO Homo sapiens GSE96659 1,837
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks