CLOCK
Information CLOCK
- Description
The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
- Full Name
clock circadian regulator
Source NCBI
- Species
Homo sapiens [tax_id: 9606]
- Genome
hg38
ReMap Statistics
- Datasets
- 15
- Biotypes
- 6
- Peaks
- 92,656
- Non-redundant peaks
- 82,106
TF Classification
- Super Class
- Basic domains
- Class
- Basic helix-loop-helix factors (bHLH)
- Familly
- PAS domain factors
- Sub Familly
- Arnt-like factors
Source TFClass
External IDs
- NCBI Gene
- 9575
- Official Gene Name
- CLOCK
- JASPAR
- MA0819
- Ensembl
- ENSG00000134852
- UniProt
- O15516
- Genevisible
- O15516
- RefSeq
- NM_001267843
- Aliases
- KAT13D; KIAA0334; bHLHe8
Datasets Table for CLOCK
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| CLOCK | K-562 | ENCODE | Homo sapiens | ENCSR228OQM | 542 | |||
| CLOCK | neural | progenitor-O62409 | GEO | Homo sapiens | GSE96659 | 408 | ||
| CLOCK | MCF-7 | ENCODE | Homo sapiens | ENCSR934JDG | 9,890 | |||
| CLOCK | MCF-7 | ENCODE | Homo sapiens | ENCSR699YFX | 10,847 | |||
| CLOCK | U2OS | GEO | Homo sapiens | GSE44236 | 24,359 | |||
| CLOCK | BA40 | 3 | GEO | Homo sapiens | GSE96659 | 14,295 | ||
| CLOCK | BA40 | 2 | GEO | Homo sapiens | GSE96659 | 1,076 | ||
| CLOCK | BA40 | 1 | GEO | Homo sapiens | GSE96659 | 981 | ||
| CLOCK | BA40 | 0 | GEO | Homo sapiens | GSE96659 | 11,399 | ||
| CLOCK | BA40 | 4 | GEO | Homo sapiens | GSE96659 | 1,763 | ||
| CLOCK | BA10 | 0 | GEO | Homo sapiens | GSE96659 | 667 | ||
| CLOCK | BA10 | 2 | GEO | Homo sapiens | GSE96659 | 11,458 | ||
| CLOCK | BA10 | 3 | GEO | Homo sapiens | GSE96659 | 1,107 | ||
| CLOCK | BA10 | 4 | GEO | Homo sapiens | GSE96659 | 2,027 | ||
| CLOCK | BA10 | 1 | GEO | Homo sapiens | GSE96659 | 1,837 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |