DLX5
Information DLX5
- Description
Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding. {ECO:0000269|PubMed:15383550, ECO:0000269|PubMed:18056716, ECO:0000269|PubMed:19956613}.(Source UnitProtKB).
- Full Name
distal-less homeobox 5
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 1
- Biotypes
- 1
- Peaks
- 16,832
- Non-redundant peaks
- 16,832
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 13395
- Official Gene Name
- Dlx5
- JASPAR
- MGI
- MGI:101926
- Ensembl
- ENSMUSG00000029755
- UniProt
- P70396
- Genevisible
- P70396
- RefSeq
- Aliases
- AI385752
Datasets Table for DLX5
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| DLX5 | ganglionic-eminence | E16-5 | GEO | Mus musculus | GSE124936 | 16,832 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |