EBF1

Information EBF1

Description

Key pioneer transcription factor of B-cell specification and commitment (PubMed:1915300, PubMed:7542362, PubMed:23812095). Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (PubMed:20876732). Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates (PubMed:23812095, PubMed:20451411). For instance, positively regulates many B-cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage (PubMed:23812095, PubMed:20451411). In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold (PubMed:32130892). {ECO:0000269|PubMed:1915300, ECO:0000269|PubMed:20451411, ECO:0000269|PubMed:20876732, ECO:0000269|PubMed:23812095, ECO:0000269|PubMed:32130892, ECO:0000269|PubMed:7542362}.(Source UnitProtKB).

Full Name

early B cell factor 1

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
33
Biotypes
10
Peaks
317,827
Non-redundant peaks
103,955

TF Classification

Familly
Rel homology region (RHR) factors
Sub Familly
Early B-Cell Factor-related factors

Source JASPAR

External IDs

NCBI Gene
13591
Official Gene Name
Ebf1
JASPAR
MA0154.1
MGI
MGI:95275
Ensembl
ENSMUSG00000057098
UniProt
Q07802
Genevisible
Q07802
RefSeq
NM_007897
Aliases
Ebf; O/E-1; OE-1; Olf-1; Olf1

External links
All peaks EBF1
Download BED file
Non redundant peaks EBF1
Download BED file
SEQUENCES EBF1
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for EBF1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
EBF1 pre-B-cell 12h GEO Mus musculus GSE53362 2,531
EBF1 pre-B-cell IKDN GEO Mus musculus GSE86897 29,291
EBF1 pre-B-cell 0h GEO Mus musculus GSE53362 4,908
EBF1 pre-B-cell 48h GEO Mus musculus GSE53362 223
EBF1 pre-B-cell WT GEO Mus musculus GSE86897 25,257
EBF1 pre-B-cell GEO Mus musculus GSE19971 5,623
EBF1 pre-B-cell 24h GEO Mus musculus GSE53362 2,493
EBF1 fetal-liver GEO Mus musculus GSE79142 4,253
EBF1 mESC GEO Mus musculus GSE136245 101
EBF1 lymph GEO Mus musculus GSE35857 550
EBF1 pro-B-cell Ebf1-pos-neg_Pax5-pos-neg GEO Mus musculus GSE69227 6,352
EBF1 pro-B-cell 72h GEO Mus musculus GSE107236 22,717
EBF1 pro-B-cell GEO Mus musculus GSE53595 7,278
EBF1 pro-B-cell Pax5-pos-neg GEO Mus musculus GSE69227 18,953
EBF1 pro-B-cell GEO Mus musculus GSE69227 9,867
EBF1 pro-B-cell H240A GEO Mus musculus GSE87636 3,964
EBF1 pro-B-cell GEO Mus musculus GSE79140 9,912
EBF1 pro-B-cell GEO Mus musculus GSE87636 4,630
EBF1 pro-B-cell Rag-neg-neg GEO Mus musculus GSE35857 8,037
EBF1 sarcoma 4d GEO Mus musculus GSE124873 16,535
EBF1 sarcoma G1297 GEO Mus musculus GSE77204 4,508
EBF1 C10 Cebpa-3h GEO Mus musculus GSE86420 5,782
EBF1 C10 Cebpa-12h GEO Mus musculus GSE86420 2,531
EBF1 C10 Cebpa-24h GEO Mus musculus GSE86420 221
EBF1 sarcoma 48h GEO Mus musculus GSE124873 9,194
EBF1 C10 GEO Mus musculus GSE86420 4,843
EBF1 pre-B-cell 3h GEO Mus musculus GSE53362 5,776
EBF1 spleen GEO Mus musculus GSE35910 3,649
EBF1 fibroblast GEO Mus musculus GSE119782 719
EBF1 pro-B-cell CD19-pos GEO Mus musculus GSE107236 24,488
EBF1 pro-B-cell 24h GEO Mus musculus GSE107236 26,442
EBF1 pro-B-cell 6h GEO Mus musculus GSE107237 31,703
EBF1 3T3-L1 GEO Mus musculus GSE58330 14,496
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks