EP300

Information EP300

Description

This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]

Full Name

E1A binding protein p300

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
43
Biotypes
23
Peaks
838,432
Non-redundant peaks
407,933

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
2033
Official Gene Name
EP300
JASPAR
Ensembl
ENSG00000100393
UniProt
Q09472
Genevisible
Q09472
RefSeq
NM_001362843
Aliases
KAT3B; MKHK2; RSTS2; p300

External links
All peaks EP300
Download BED file
Non redundant peaks EP300
Download BED file
SEQUENCES EP300
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for EP300

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
EP300 MCF-7 E2 GEO Homo sapiens GSE29073 2,291
EP300 MCF-7 DMSO GEO Homo sapiens GSE29073 2,463
EP300 MCF-7 shCtrl GEO Homo sapiens GSE128445 29,010
EP300 MCF-7 TamR GEO Homo sapiens GSE128445 6,676
EP300 MCF-7 GEO Homo sapiens GSE128445 14,301
EP300 MCF-7 shJUN GEO Homo sapiens GSE128445 2,237
EP300 PC-3 GEO Homo sapiens GSE147455 51,947
EP300 697 GEO Homo sapiens GSE138031 10,146
EP300 Kasumi-1 GEO Homo sapiens GSE115115 16,542
EP300 NB4 GEO Homo sapiens GSE126720 6,917
EP300 WA01 ENCODE Homo sapiens ENCSR000AUQ 9,125
EP300 WA01 ENCODE Homo sapiens ENCSR000BKK 19,842
EP300 T-47D ENCODE Homo sapiens ENCSR000BLM 26,654
EP300 SK-N-SH ENCODE Homo sapiens ENCSR000BUA 42,813
EP300 SK-N-SH ENCODE Homo sapiens ENCSR000EHV 42,833
EP300 MCF-7 ENCODE Homo sapiens ENCSR000BTR 15,787
EP300 K-562 ENCODE Homo sapiens ENCSR000EGY 3,222
EP300 K-562 ENCODE Homo sapiens ENCSR000AQB 184
EP300 K-562 ENCODE Homo sapiens ENCSR000EGE 41,225
EP300 Hep-G2 ENCODE Homo sapiens ENCSR000EDV 18,081
EP300 Hep-G2 ENCODE Homo sapiens ENCSR000BLW 55,091
EP300 A-549 ENCODE Homo sapiens ENCSR000BPW 34,541
EP300 osteoblast ENCODE Homo sapiens ENCSR000AUD 16,648
EP300 neural ENCODE Homo sapiens ENCSR843ZUP 47,786
EP300 Ishikawa ENCODE Homo sapiens ENCSR000BUE 36,973
EP300 GM12878 ENCODE Homo sapiens ENCSR000DZD 5,603
EP300 GM12878 ENCODE Homo sapiens ENCSR000DZG 6,680
EP300 GM12878 ENCODE Homo sapiens ENCSR000BHB 9,864
EP300 hESC GEO Homo sapiens GSE17917 2,836
EP300 NCI-H1299 ctrl GEO Homo sapiens GSE109591 103
EP300 fibroblast proliferating GEO Homo sapiens GSE106146 28,873
EP300 fibroblast senescent GEO Homo sapiens GSE106146 30,721
EP300 LNCaP-FGC A485 GEO Homo sapiens GSE124642 652
EP300 LNCaP-FGC ICPB112 GEO Homo sapiens GSE124642 8,758
EP300 LNCaP-FGC DMSO GEO Homo sapiens GSE124642 489
EP300 AML shaml1-eto GEO Homo sapiens GSE131939 21,429
EP300 AML GEO Homo sapiens GSE131939 50,712
EP300 HeLa-S3 ENCODE Homo sapiens ENCSR000ECV 33,576
EP300 HeLa-S3 ENCODE Homo sapiens ENCSR680OFU 46,614
EP300 HCT-116 DMSO GEO Homo sapiens GSE125927 195
EP300 HCT-116 Nutlin3a GEO Homo sapiens GSE125927 364
EP300 pulmonary-artery endothelial-cell_siPFKFB3 GEO Homo sapiens GSE89786 15,131
EP300 pulmonary-artery endothelial-cell_siCtrl GEO Homo sapiens GSE89786 22,497
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks