ETV1

Information ETV1

Description

This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2016]

Full Name

ETS variant transcription factor 1

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
12
Biotypes
10
Peaks
191,620
Non-redundant peaks
105,388

TF Classification

Super Class
Helix-turn-helix domains
Class
Tryptophan cluster factors
Familly
Ets-related factors
Sub Familly
Elk-like factors

Source TFClass

External IDs

NCBI Gene
2115
Official Gene Name
ETV1
JASPAR
MA0761
Ensembl
ENSG00000006468
UniProt
P50549
Genevisible
P50549
RefSeq
NM_001163147
Aliases
ER81
All peaks ETV1
Download BED file
Non redundant peaks ETV1
Download BED file
SEQUENCES ETV1
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for ETV1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
ETV1 GIST GEO Homo sapiens GSE22441 21,887
ETV1 GIST-T1 GEO Homo sapiens GSE80443 14,557
ETV1 GIST-T1 GEO Homo sapiens GSE106624 42,115
ETV1 A-375 GEO Homo sapiens GSE80443 6,084
ETV1 RWPE-1 FLAG GEO Homo sapiens GSE29808 1,164
ETV1 GIST48 iFOXF1 GEO Homo sapiens GSE106624 841
ETV1 MDA-Pca-2b GEO Homo sapiens GSE106624 33,696
ETV1 LNCaP GEO Homo sapiens GSE47120 24,354
ETV1 K-562 ENCODE Homo sapiens ENCSR277DMR 12,250
ETV1 GIST48 siSCR GEO Homo sapiens GSE106624 3,378
ETV1 GIST882 GEO Homo sapiens GSE80443 4,355
ETV1 COLO-800 GEO Homo sapiens GSE80443 26,939
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks