HEY1
Information HEY1
- Description
Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3. {ECO:0000269|PubMed:11095750, ECO:0000269|PubMed:11486045, ECO:0000269|PubMed:12947105, ECO:0000269|PubMed:15107403, ECO:0000269|PubMed:15680351, ECO:0000269|PubMed:16199874, ECO:0000269|PubMed:17259303, ECO:0000269|PubMed:17303760}.
- Full Name
hairy/enhancer-of-split related with YRPW motif 1
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 2
- Biotypes
- 1
- Peaks
- 25,958
- Non-redundant peaks
- 23,836
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 15213
- Official Gene Name
- Hey1
- JASPAR
- MGI
- MGI:1341800
- Ensembl
- ENSMUSG00000040289
- UniProt
- Q9WV93
- Genevisible
- Q9WV93
- RefSeq
- NM_010423
- Aliases
- AI316788; AI414254; CHF2; HRT1; Herp2; Hesr1; bHLHb31; hesr-1
Datasets Table for HEY1
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| HEY1 | CM7-1 | cardiomyocyte_Dox | GEO | Mus musculus | GSE60699 | 18,040 | ||
| HEY1 | CM7-1 | mESC | GEO | Mus musculus | GSE60699 | 7,918 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |