HEY2
Information HEY2
- Description
Transcriptional repressor which functions as a downstream effector of Notch signaling in cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY1 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3. {ECO:0000269|PubMed:10692439, ECO:0000269|PubMed:11095750, ECO:0000269|PubMed:11160397, ECO:0000269|PubMed:11486045, ECO:0000269|PubMed:12372253, ECO:0000269|PubMed:12372254, ECO:0000269|PubMed:12454287, ECO:0000269|PubMed:12947105, ECO:0000269|PubMed:15107403, ECO:0000269|PubMed:15297376, ECO:0000269|PubMed:15345511, ECO:0000269|PubMed:15485867, ECO:0000269|PubMed:15680351, ECO:0000269|PubMed:16199874, ECO:0000269|PubMed:17259303, ECO:0000269|PubMed:17303760, ECO:0000269|PubMed:17332425}.(Source UnitProtKB).
- Full Name
hairy/enhancer-of-split related with YRPW motif 2
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 4
- Biotypes
- 1
- Peaks
- 86,463
- Non-redundant peaks
- 67,745
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 15214
- Official Gene Name
- Hey2
- JASPAR
- MGI
- MGI:1341884
- Ensembl
- ENSMUSG00000019789
- UniProt
- Q9QUS4
- Genevisible
- Q9QUS4
- RefSeq
- NM_013904
- Aliases
- CHF1; Herp1; Hesr2; Hrt2; bHLHb32; hesr2
Datasets Table for HEY2
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| HEY2 | CM7-1 | cardiomyocyte_Dox | GEO | Mus musculus | GSE60699 | 18,759 | ||
| HEY2 | CM7-1 | mESC | GEO | Mus musculus | GSE60699 | 10,218 | ||
| HEY2 | CM7-1 | mESC_Dox | GEO | Mus musculus | GSE60699 | 57,125 | ||
| HEY2 | CM7-1 | cardiomyocyte | GEO | Mus musculus | GSE60699 | 361 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |