HIF1A

Information HIF1A

Description

This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]

Full Name

hypoxia inducible factor 1 subunit alpha

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
26
Biotypes
13
Peaks
282,059
Non-redundant peaks
172,435

TF Classification

Super Class
Basic domains
Class
Basic helix-loop-helix factors (bHLH)
Familly
PAS domain factors
Sub Familly
Ahr-like factors

Source TFClass

External IDs

NCBI Gene
3091
Official Gene Name
HIF1A
JASPAR
MA1106
Ensembl
ENSG00000100644
UniProt
Q16665
Genevisible
Q16665
RefSeq
NM_001243084
Aliases
HIF-1-alpha; HIF-1A; HIF-1alpha; HIF1; HIF1-ALPHA; MOP1; PASD8; bHLHe78

External links
All peaks HIF1A
Download BED file
Non redundant peaks HIF1A
Download BED file
SEQUENCES HIF1A
Download FASTA file
DOWNLOAD All ReMap
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Datasets Table for HIF1A

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
HIF1A macrophage HYPO GEO Homo sapiens GSE43109 9,039
HIF1A macrophage NORMO_IL GEO Homo sapiens GSE43109 152
HIF1A macrophage HYPO_IL GEO Homo sapiens GSE43109 2,091
HIF1A RCC10 GEO Homo sapiens GSE101063 5,074
HIF1A 501-mel GEO Homo sapiens GSE95280 6,231
HIF1A PC-3 siOC2 GEO Homo sapiens GSE106305 23,395
HIF1A PC-3 hypoxia_siSMAD3 GEO Homo sapiens GSE106305 11,822
HIF1A PC-3 hypoxia_siCtrl GEO Homo sapiens GSE106305 50,352
HIF1A K-562 hypoxia GEO Homo sapiens GSE142865 2,071
HIF1A K-562 GEO Homo sapiens GSE123461 4,665
HIF1A K-562 normoxia GEO Homo sapiens GSE142865 124
HIF1A LNCaP androgen-N_hypoxia-N GEO Homo sapiens GSE114732 6,896
HIF1A LNCaP androgen-N_hypoxia-Y GEO Homo sapiens GSE114732 13,632
HIF1A LNCaP androgen-Y_hypoxia-Y GEO Homo sapiens GSE114732 1,203
HIF1A MDA-MB-231 GEO Homo sapiens GSE108833 5,137
HIF1A BEAS-2B arsenic GEO Homo sapiens GSE145834 44,518
HIF1A BEAS-2B GEO Homo sapiens GSE145834 28,664
HIF1A HUVEC-C NOMO GEO Homo sapiens GSE39089 339
HIF1A HUVEC-C HYPOX GEO Homo sapiens GSE39089 3,417
HIF1A 786-O GEO Homo sapiens GSE34871 2,552
HIF1A U2OS DMSO GEO Homo sapiens GSE85096 7,636
HIF1A U2OS trough_DMOG GEO Homo sapiens GSE85096 27,510
HIF1A U2OS DMOG GEO Homo sapiens GSE85096 19,061
HIF1A U2OS trough_DMSO GEO Homo sapiens GSE85096 3,182
HIF1A NCI-H1299 GEO Homo sapiens GSE76770 2,664
HIF1A ccRCC GEO Homo sapiens GSE86092 632
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks