HNF4A

Information HNF4A

Description

The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]

Full Name

hepatocyte nuclear factor 4 alpha

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
20
Biotypes
11
Peaks
572,696
Non-redundant peaks
232,794

TF Classification

Super Class
Zinc-coordinating DNA-binding domains
Class
Nuclear receptors with C4 zinc fingers
Familly
RXR-related receptors (NR2)
Sub Familly
HNF-4 (NR2A)

Source TFClass

External IDs

NCBI Gene
3172
Official Gene Name
HNF4A
JASPAR
MA0114
Ensembl
ENSG00000101076
UniProt
P41235
Genevisible
P41235
RefSeq
NM_000457
Aliases
FRTS4; HNF4; HNF4a7; HNF4a8; HNF4a9; HNF4alpha; MODY; MODY1; NR2A1; NR2A21; TCF; TCF14

External links
All peaks HNF4A
Download BED file
Non redundant peaks HNF4A
Download BED file
SEQUENCES HNF4A
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for HNF4A

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
HNF4A HCCLM3 High-Glucose GEO Homo sapiens GSE101553 2,509
HNF4A HCCLM3 Low-Glucose GEO Homo sapiens GSE101553 1,240
HNF4A LoVo PHASES GEO Homo sapiens GSE51290 11,657
HNF4A LoVo PHASEM GEO Homo sapiens GSE51290 1,507
HNF4A IM95 GEO Homo sapiens GSE114018 59,587
HNF4A GP5D SIRAD21 GEO Homo sapiens GSE51234 4,148
HNF4A GP5D GEO Homo sapiens GSE51234 14,879
HNF4A Hep-G2 ENCODE Homo sapiens ENCSR469FBY 73,059
HNF4A Hep-G2 ENCODE Homo sapiens ENCSR000BLF 62,630
HNF4A Hep-G2 ENA Homo sapiens ERP000209 39,187
HNF4A Hep-G2 ENCODE Homo sapiens ENCSR000EEU 21,163
HNF4A liver ENA Homo sapiens ERP002306 64,640
HNF4A Caco-2 DIFF GEO Homo sapiens GSE23436 64,374
HNF4A Caco-2 PROLIF GEO Homo sapiens GSE23436 19,748
HNF4A hiPSC GEO Homo sapiens GSE104613 4,627
HNF4A HCT-116 TCF4 GEO Homo sapiens GSE62890 3,900
HNF4A HCT-116 TCF4_DOX GEO Homo sapiens GSE62890 2,909
HNF4A HCT-116 GEO Homo sapiens GSE62890 6,745
HNF4A KATO-III GEO Homo sapiens GSE114018 58,491
HNF4A gastric-epithelial-cell OE GEO Homo sapiens GSE114018 55,696
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks