IRF3
Information IRF3
- Description
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. The protein plays an important role in the innate immune response against DNA and RNA viruses. Mutations in this gene are associated with Encephalopathy, acute, infection-induced, herpes-specific, 7. [provided by RefSeq, Sep 2020]
- Full Name
interferon regulatory factor 3
Source NCBI
- Species
Homo sapiens [tax_id: 9606]
- Genome
hg38
ReMap Statistics
- Datasets
- 7
- Biotypes
- 6
- Peaks
- 9,126
- Non-redundant peaks
- 5,162
TF Classification
- Super Class
- Helix-turn-helix domains
- Class
- Tryptophan cluster factors
- Familly
- Interferon-regulatory factors
- Sub Familly
- None
Source TFClass
External IDs
- NCBI Gene
- 3661
- Official Gene Name
- IRF3
- JASPAR
- MA1418
- Ensembl
- ENSG00000126456
- UniProt
- Q14653
- Genevisible
- Q14653
- RefSeq
- NM_001197122
- Aliases
- IIAE7
Datasets Table for IRF3
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| IRF3 | BC-3 | GEO | Homo sapiens | GSE132777 | 138 | |||
| IRF3 | SK-N-SH | ENCODE | Homo sapiens | ENCSR422ZAO | 2,712 | |||
| IRF3 | Hep-G2 | ENCODE | Homo sapiens | ENCSR000EEJ | 582 | |||
| IRF3 | GM12878 | ENCODE | Homo sapiens | ENCSR408JQO | 3,687 | |||
| IRF3 | GM12878 | ENCODE | Homo sapiens | ENCSR000DZX | 463 | |||
| IRF3 | HeLa-S3 | ENCODE | Homo sapiens | ENCSR000EDF | 1,399 | |||
| IRF3 | HBTEC | E1Ainfected_FOXKb | GEO | Homo sapiens | GSE105037 | 145 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |