IRF4
Information IRF4
- Description
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]
- Full Name
interferon regulatory factor 4
Source NCBI
- Species
Homo sapiens [tax_id: 9606]
- Genome
hg38
ReMap Statistics
- Datasets
- 14
- Biotypes
- 10
- Peaks
- 350,445
- Non-redundant peaks
- 176,337
TF Classification
- Super Class
- Helix-turn-helix domains
- Class
- Tryptophan cluster factors
- Familly
- Interferon-regulatory factors
- Sub Familly
- None
Source TFClass
External IDs
- NCBI Gene
- 3662
- Official Gene Name
- IRF4
- JASPAR
- MA1419
- Ensembl
- ENSG00000137265
- UniProt
- Q15306
- Genevisible
- Q15306
- RefSeq
- NM_001195286
- Aliases
- LSIRF; MUM1; NF-EM5; SHEP8
Datasets Table for IRF4
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| IRF4 | KK-1 | GEO | Homo sapiens | GSE94732 | 5,072 | |||
| IRF4 | NCI-H929 | GEO | Homo sapiens | GSE56857 | 40,496 | |||
| IRF4 | NCI-H929 | GEO | Homo sapiens | GSE142493 | 27,448 | |||
| IRF4 | BC-3 | GEO | Homo sapiens | GSE132777 | 29,535 | |||
| IRF4 | OCI-Ly10 | GEO | Homo sapiens | GSE142493 | 20,697 | |||
| IRF4 | GM12878 | ENCODE | Homo sapiens | ENCSR000BGY | 57,242 | |||
| IRF4 | OCI-Ly3 | GEO | Homo sapiens | GSE142493 | 13,563 | |||
| IRF4 | OCI-Ly3 | SHSPIB | GEO | Homo sapiens | GSE56857 | 747 | ||
| IRF4 | OCI-Ly3 | SHCTR | GEO | Homo sapiens | GSE56857 | 8,295 | ||
| IRF4 | OCI-Ly3 | GEO | Homo sapiens | GSE56857 | 9,082 | |||
| IRF4 | T-cell | GEO | Homo sapiens | GSE136853 | 65,369 | |||
| IRF4 | plasmablast | GEO | Homo sapiens | GSE142493 | 4,214 | |||
| IRF4 | B-cell | GEO | Homo sapiens | GSE142493 | 42,313 | |||
| IRF4 | U266 | GEO | Homo sapiens | GSE142493 | 26,372 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |