KDM4A
Information KDM4A
- Description
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:24953653). Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively (By similarity). {ECO:0000250|UniProtKB:O75164, ECO:0000269|PubMed:24953653}.(Source UnitProtKB).
- Full Name
lysine (K)-specific demethylase 4A
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 4
- Biotypes
- 3
- Peaks
- 30,592
- Non-redundant peaks
- 25,769
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 230674
- Official Gene Name
- Kdm4a
- JASPAR
- MGI
- MGI:2446210
- Ensembl
- ENSMUSG00000033326
- UniProt
- Q8BW72
- Genevisible
- Q8BW72
- RefSeq
- NM_172382
- Aliases
- D4Ertd222e; JHDM3A; Jmjd2; Jmjd2a
Datasets Table for KDM4A
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| KDM4A | uterus | WT1 | GEO | Mus musculus | GSE96591 | 156 | ||
| KDM4A | mESC | GEO | Mus musculus | GSE64252 | 21,004 | |||
| KDM4A | mESC | OHT | GEO | Mus musculus | GSE64252 | 162 | ||
| KDM4A | MLL-AF9 | ctrl | GEO | Mus musculus | GSE81299 | 9,270 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |