KMT2A

Information KMT2A

Description

This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]

Full Name

lysine methyltransferase 2A

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
41
Biotypes
17
Peaks
779,104
Non-redundant peaks
285,417

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
4297
Official Gene Name
KMT2A
JASPAR
Ensembl
ENSG00000118058
UniProt
Q03164
Genevisible
Q03164
RefSeq
NM_001197104
Aliases
ALL-1; CXXC7; HRX; HTRX1; MLL; MLL1; MLL1A; TRX1; WDSTS

External links
All peaks KMT2A
Download BED file
Non redundant peaks KMT2A
Download BED file
SEQUENCES KMT2A
Download FASTA file
DOWNLOAD All ReMap
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Datasets Table for KMT2A

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
KMT2A MCF-7 C-term_TTP22 GEO Homo sapiens GSE90762 7,234
KMT2A MCF-7 C-term_CX4945 GEO Homo sapiens GSE90762 5,717
KMT2A MCF-7 C-term_DMSO GEO Homo sapiens GSE90762 4,934
KMT2A RCH-ACV GEO Homo sapiens GSE83671 45,743
KMT2A OCI-AML-3 DMSO GEO Homo sapiens GSE129636 25,208
KMT2A OCI-AML-3 VTP GEO Homo sapiens GSE129636 24,869
KMT2A MV4-11 GEO Homo sapiens GSE83671 22,322
KMT2A MV4-11 GEO Homo sapiens GSE79899 24,918
KMT2A HEK293T C-term_shCtrl_TASP1-KO GEO Homo sapiens GSE90762 12,965
KMT2A HEK293T N-term_C104 GEO Homo sapiens GSE90762 19,559
KMT2A HEK293T N-term GEO Homo sapiens GSE90762 13,473
KMT2A HEK293T C-term_shCtrl GEO Homo sapiens GSE90762 9,137
KMT2A HEK293T C-term GEO Homo sapiens GSE90762 10,327
KMT2A HEK293T N-term_C49 GEO Homo sapiens GSE90762 17,143
KMT2A HEK293T C-term_C104 GEO Homo sapiens GSE90762 14,549
KMT2A HEK293T C-term_C49 GEO Homo sapiens GSE90762 14,469
KMT2A HEK293T N-term_shCtrl_TASP1-KO GEO Homo sapiens GSE90762 18,058
KMT2A HEK293T N-term_shCtrl GEO Homo sapiens GSE90762 14,709
KMT2A HEK293T N-term_shMLL1 GEO Homo sapiens GSE90762 423
KMT2A MOLM-13 GEO Homo sapiens GSE114981 19,717
KMT2A MOLM-13 DMSO-D3-180110 GEO Homo sapiens GSE127507 16,314
KMT2A MOLM-13 CBS79-KO-VP-HOTTIP GEO Homo sapiens GSE114981 26,401
KMT2A MOLM-13 VTP-d3-180110 GEO Homo sapiens GSE127507 30,136
KMT2A MOLM-13 HOTTIP-KO GEO Homo sapiens GSE114981 8,946
KMT2A MOLM-13 CBS79-KO GEO Homo sapiens GSE114981 2,050
KMT2A KOPN-8 GEO Homo sapiens GSE83671 23,095
KMT2A THP-1 GEO Homo sapiens GSE83671 13,732
KMT2A THP-1 GEO Homo sapiens GSE79899 22,635
KMT2A IMS-M2 VTP GEO Homo sapiens GSE129636 14,864
KMT2A IMS-M2 DMSO GEO Homo sapiens GSE129636 23,304
KMT2A SHI-1 GEO Homo sapiens GSE95511 11,852
KMT2A SEM GEO Homo sapiens GSE83671 24,887
KMT2A CCRF-CEM GEO Homo sapiens GSE83671 27,434
KMT2A Hep-G2 ENCODE Homo sapiens ENCSR692GFR 76,752
KMT2A ML-2 VTP-d3 GEO Homo sapiens GSE127507 2,986
KMT2A ML-2 DMSO-D3 GEO Homo sapiens GSE127507 2,348
KMT2A blood cord GEO Homo sapiens GSE83671 47,414
KMT2A L826 GEO Homo sapiens GSE83671 41,261
KMT2A RS4-11 GEO Homo sapiens GSE38403 9,729
KMT2A RS4-11 DMSO-D3-180402 GEO Homo sapiens GSE127507 15,295
KMT2A RS4-11 VTP-d3-180402 GEO Homo sapiens GSE127507 12,195
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks