MAX
Information MAX
- Description
The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
- Full Name
MYC associated factor X
Source NCBI
- Species
Homo sapiens [tax_id: 9606]
- Genome
hg38
ReMap Statistics
- Datasets
- 32
- Biotypes
- 20
- Peaks
- 1,179,875
- Non-redundant peaks
- 368,527
TF Classification
- Super Class
- Basic domains
- Class
- Basic helix-loop-helix factors (bHLH)
- Familly
- bHLH-ZIP factors
- Sub Familly
- Myc / Max factors
Source TFClass
External IDs
- NCBI Gene
- 4149
- Official Gene Name
- MAX
- JASPAR
- MA0059
- Ensembl
- ENSG00000125952
- UniProt
- P61244
- Genevisible
- P61244
- RefSeq
- NM_001271068
- Aliases
- bHLHd4
Datasets Table for MAX
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| MAX | NCI-H128 | GEO | Homo sapiens | GSE41105 | 26,409 | |||
| MAX | MDA-MB-468 | GEO | Homo sapiens | GSE81381 | 31,616 | |||
| MAX | melanocyte | GEO | Homo sapiens | GSE115845 | 10,150 | |||
| MAX | Hep-G2 | ENCODE | Homo sapiens | ENCSR168DYA | 66,285 | |||
| MAX | NCI-H2171 | GEO | Homo sapiens | GSE41105 | 77,408 | |||
| MAX | NCI-H2171 | GEO | Homo sapiens | GSE36354 | 77,104 | |||
| MAX | MDA-MB-231 | GEO | Homo sapiens | GSE127192 | 20,836 | |||
| MAX | WA01 | ENCODE | Homo sapiens | ENCSR000EUP | 24,843 | |||
| MAX | SK-N-SH | ENCODE | Homo sapiens | ENCSR000BVD | 62,803 | |||
| MAX | MCF-7 | ENCODE | Homo sapiens | ENCSR000BUL | 66,912 | |||
| MAX | K-562 | ENCODE | Homo sapiens | ENCSR000FAE | 9,793 | |||
| MAX | K-562 | ENCODE | Homo sapiens | ENCSR000EFV | 75,392 | |||
| MAX | Hep-G2 | ENCODE | Homo sapiens | ENCSR000EDS | 32,198 | |||
| MAX | Hep-G2 | ENCODE | Homo sapiens | ENCSR000BTM | 58,647 | |||
| MAX | A-549 | ENCODE | Homo sapiens | ENCSR000DYG | 15,602 | |||
| MAX | A-549 | ENCODE | Homo sapiens | ENCSR000BTJ | 45,927 | |||
| MAX | NB4 | ENCODE | Homo sapiens | ENCSR000EHS | 13,556 | |||
| MAX | liver | ENCODE | Homo sapiens | ENCSR521IID | 34,558 | |||
| MAX | liver | ENCODE | Homo sapiens | ENCSR847DIT | 43,863 | |||
| MAX | Ishikawa | ENCODE | Homo sapiens | ENCSR000BTY | 53,021 | |||
| MAX | GM12878 | ENCODE | Homo sapiens | ENCSR000DZF | 3,694 | |||
| MAX | endothelial | umbilical-vein | ENCODE | Homo sapiens | ENCSR000EEZ | 25,524 | ||
| MAX | P493-6 | 24HR | GEO | Homo sapiens | GSE125863 | 23,404 | ||
| MAX | P493-6 | 4HR | GEO | Homo sapiens | GSE125863 | 19,818 | ||
| MAX | P493-6 | CMYC_1H | GEO | Homo sapiens | GSE36354 | 38,308 | ||
| MAX | P493-6 | GEO | Homo sapiens | GSE36354 | 48,148 | |||
| MAX | P493-6 | CMYC_24H | GEO | Homo sapiens | GSE36354 | 18,834 | ||
| MAX | P493-6 | GEO | Homo sapiens | GSE42262 | 27,560 | |||
| MAX | MM1-S | JQ1 | GEO | Homo sapiens | GSE42161 | 278 | ||
| MAX | HeLa-S3 | ENCODE | Homo sapiens | ENCSR000EZF | 56,449 | |||
| MAX | HeLa-S3 | ENCODE | Homo sapiens | ENCSR000ECN | 45,287 | |||
| MAX | HCT-116 | ENCODE | Homo sapiens | ENCSR000BSH | 25,648 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |