MED1

Information MED1

Description

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008]

Full Name

mediator complex subunit 1

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
90
Biotypes
33
Peaks
2,011,532
Non-redundant peaks
543,933

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
5469
Official Gene Name
MED1
JASPAR
Ensembl
ENSG00000125686
UniProt
Q15648
Genevisible
Q15648
RefSeq
NM_004774
Aliases
CRSP1; CRSP200; DRIP205; DRIP230; PBP; PPARBP; PPARGBP; RB18A; TRAP220; TRIP2

External links
All peaks MED1
Download BED file
Non redundant peaks MED1
Download BED file
SEQUENCES MED1
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for MED1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
MED1 MCF-7 SHCTR GEO Homo sapiens GSE60270 23,384
MED1 MCF-7 SHCTR_E2 GEO Homo sapiens GSE60270 17,743
MED1 MCF-7 E2 GEO Homo sapiens GSE60270 6,677
MED1 SGBS GEO Homo sapiens GSE64233 44,404
MED1 SGBS TNF GEO Homo sapiens GSE64233 28,730
MED1 A-549 GEO Homo sapiens GSE76893 13,509
MED1 myoblast GEO Homo sapiens GSE60026 11,975
MED1 MOLM-13 GEO Homo sapiens GSE154985 12,759
MED1 OCI-Ly1 GEO Homo sapiens GSE53601 3,296
MED1 VCaP GEO Homo sapiens GSE148358 32,704
MED1 VCaP R1881 GEO Homo sapiens GSE148358 35,548
MED1 VCaP Darolutamide GEO Homo sapiens GSE148358 18,842
MED1 VCaP Veh GEO Homo sapiens GSE125245 10,236
MED1 VCaP DHT GEO Homo sapiens GSE125245 16,360
MED1 VCaP DHTENZA GEO Homo sapiens GSE125245 821
MED1 VCaP DHTTHZ1 GEO Homo sapiens GSE125245 16,967
MED1 GM12878 GEO Homo sapiens GSE93080 40,415
MED1 697 GEO Homo sapiens GSE138031 1,039
MED1 hMSC-TERT4 D7 GEO Homo sapiens GSE104537 44,986
MED1 hMSC-TERT4 D3 GEO Homo sapiens GSE104537 50,408
MED1 hMSC-TERT4 D0 GEO Homo sapiens GSE104537 17,719
MED1 hMSC-TERT4 D1 GEO Homo sapiens GSE104537 5,848
MED1 hMSC-TERT4 D14 GEO Homo sapiens GSE104537 36,796
MED1 hMSC-TERT4 4h GEO Homo sapiens GSE104537 67,959
MED1 hMSC-TERT4 adipocyte-4H GEO Homo sapiens GSE113253 48,259
MED1 hMSC-TERT4 osteoblast-D1 GEO Homo sapiens GSE113253 32,667
MED1 hMSC-TERT4 osteoblast-D3 GEO Homo sapiens GSE113253 39,486
MED1 hMSC-TERT4 osteoblast-D7 GEO Homo sapiens GSE113253 49,744
MED1 hMSC-TERT4 osteoblast-4H GEO Homo sapiens GSE113253 51,443
MED1 hMSC-TERT4 adipocyte-D7 GEO Homo sapiens GSE113253 26,133
MED1 hMSC-TERT4 adipocyte-D1 GEO Homo sapiens GSE113253 31,858
MED1 hMSC-TERT4 adipocyte-D3 GEO Homo sapiens GSE113253 32,843
MED1 hMSC-TERT4 adipocyte-D14 GEO Homo sapiens GSE113253 17,540
MED1 hMSC-TERT4 undifferentiated GEO Homo sapiens GSE113253 42,736
MED1 MOLM-14 GEO Homo sapiens GSE65138 18,485
MED1 MOLM-14 DHE GEO Homo sapiens GSE124963 14,278
MED1 MOLM-14 Veh GEO Homo sapiens GSE124963 13,763
MED1 Jurkat GEO Homo sapiens GSE59657 13,546
MED1 RH4 GEO Homo sapiens GSE83726 28,052
MED1 Hep-G2 GEO Homo sapiens GSE76893 18,145
MED1 Hep-G2 ENCODE Homo sapiens ENCSR959XNY 54,692
MED1 UCSD-AML1 GEO Homo sapiens GSE154985 5,453
MED1 NCI-H2171 GEO Homo sapiens GSE36354 14,488
MED1 K-562 GEO Homo sapiens GSE97661 3,439
MED1 LNCaP DHT GEO Homo sapiens GSE125245 2,292
MED1 LNCaP Veh GEO Homo sapiens GSE125245 12,347
MED1 LNCaP DHTTHZ1 GEO Homo sapiens GSE125245 3,292
MED1 MDA-MB-231 LQ GEO Homo sapiens GSE95121 5,218
MED1 MDA-MB-231 45min GEO Homo sapiens GSE95121 562
MED1 MDA-MB-231 LQ_45min GEO Homo sapiens GSE95121 3,942
MED1 MDA-MB-231 GEO Homo sapiens GSE95121 725
MED1 HUVEC-C siCTL GEO Homo sapiens GSE124892 63,750
MED1 HUVEC-C siERG GEO Homo sapiens GSE124892 51,594
MED1 MCF-7 SHRARS_E2 GEO Homo sapiens GSE60270 36,373
MED1 MCF-7 GEO Homo sapiens GSE76893 4,728
MED1 MCF-7 SHRARS GEO Homo sapiens GSE60270 47,339
MED1 SUM159PT 100nMtrametinib_24h GEO Homo sapiens GSE87418 21,488
MED1 SUM159PT 300nMJQ1_24h GEO Homo sapiens GSE87418 23,632
MED1 SUM159PT DMSO_24h GEO Homo sapiens GSE87418 23,002
MED1 SUM159PT 100nMtrametinib300nMJQ1_24h GEO Homo sapiens GSE87418 12,382
MED1 LS180 GEO Homo sapiens GSE39277 2,720
MED1 LS180 125 GEO Homo sapiens GSE39277 1,550
MED1 CD4 Th1_DMSO GEO Homo sapiens GSE62482 10,363
MED1 CD4 Th1_BAY GEO Homo sapiens GSE62482 8,983
MED1 hESC PRIMED GEO Homo sapiens GSE69646 11,170
MED1 P493-6 GEO Homo sapiens GSE36354 12,353
MED1 P493-6 CMYC_1H GEO Homo sapiens GSE36354 2,469
MED1 P493-6 CMYC_24H GEO Homo sapiens GSE36354 1,046
MED1 MM1-S DMSO GEO Homo sapiens GSE36354 848
MED1 MM1-S JQ1_5000NM GEO Homo sapiens GSE49224 37,575
MED1 MM1-S JQ1 GEO Homo sapiens GSE42161 34,485
MED1 MM1-S BIORU GEO Homo sapiens GSE45984 2,433
MED1 MM1-S JQ1_50NM GEO Homo sapiens GSE49224 53,550
MED1 MM1-S JQ1_500NM GEO Homo sapiens GSE42355 43,537
MED1 MM1-S JQ1_5NM GEO Homo sapiens GSE49224 51,883
MED1 U-87MG GEO Homo sapiens GSE36354 57,734
MED1 AML GEO Homo sapiens GSE154985 7,532
MED1 HCT-116 thaps GEO Homo sapiens GSE121798 31,863
MED1 HCT-116 GEO Homo sapiens GSE121798 35,902
MED1 HCT-116 shLuc GEO Homo sapiens GSE121798 40,224
MED1 HCT-116 shLuc_thaps GEO Homo sapiens GSE121798 39,609
MED1 dopaminergic-neuron Dopamine_neurons GEO Homo sapiens GSE93905 11,131
MED1 adipocyte GEO Homo sapiens GSE140782 8,792
MED1 G296S GEO Homo sapiens GSE85628 13,668
MED1 G296S 2 GEO Homo sapiens GSE85628 13,681
MED1 G296S 4 GEO Homo sapiens GSE85628 19,643
MED1 cardiomyocyte 7 GEO Homo sapiens GSE85628 7,329
MED1 cardiomyocyte 5 GEO Homo sapiens GSE85628 16,574
MED1 cardiomyocyte GEO Homo sapiens GSE85628 2,020
MED1 cardiomyocyte 1 GEO Homo sapiens GSE85628 2,024
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks