MXI1

Information MXI1

Description

Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008]

Full Name

MAX interactor 1, dimerization protein

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
8
Biotypes
8
Peaks
172,578
Non-redundant peaks
91,912

TF Classification

Super Class
Basic domains
Class
Basic helix-loop-helix factors (bHLH)
Familly
bHLH-ZIP factors
Sub Familly
Mad-like factors

Source TFClass

External IDs

NCBI Gene
4601
Official Gene Name
MXI1
JASPAR
MA1108
Ensembl
ENSG00000119950
UniProt
P50539
Genevisible
P50539
RefSeq
NM_001008541
Aliases
MAD2; MXD2; MXI; bHLHc11
All peaks MXI1
Download BED file
Non redundant peaks MXI1
Download BED file
SEQUENCES MXI1
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for MXI1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
MXI1 WA01 ENCODE Homo sapiens ENCSR000EBR 11,430
MXI1 SK-N-SH ENCODE Homo sapiens ENCSR000EIA 45,067
MXI1 K-562 ENCODE Homo sapiens ENCSR000EGZ 11,785
MXI1 IMR-90 ENCODE Homo sapiens ENCSR000EFE 40,944
MXI1 Hep-G2 ENCODE Homo sapiens ENCSR000EDU 18,671
MXI1 neural ENCODE Homo sapiens ENCSR934NHU 16,559
MXI1 GM12878 ENCODE Homo sapiens ENCSR000DZI 5,875
MXI1 HeLa-S3 ENCODE Homo sapiens ENCSR000ECU 22,247
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks