MYCN

Information MYCN

Description

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

Full Name

MYCN proto-oncogene, bHLH transcription factor

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
38
Biotypes
19
Peaks
879,892
Non-redundant peaks
258,176

TF Classification

Super Class
Basic domains
Class
Basic helix-loop-helix factors (bHLH)
Familly
bHLH-ZIP factors
Sub Familly
Myc / Max factors

Source TFClass

External IDs

NCBI Gene
4613
Official Gene Name
MYCN
JASPAR
MA0104
Ensembl
ENSG00000134323
UniProt
P04198
Genevisible
P04198
RefSeq
NM_001293228
Aliases
MODED; MYCNOT; N-myc; NMYC; ODED; bHLHe37

External links
All peaks MYCN
Download BED file
Non redundant peaks MYCN
Download BED file
SEQUENCES MYCN
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for MYCN

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
MYCN CHP-134 GEO Homo sapiens GSE129588 30,928
MYCN BE2C GEO Homo sapiens GSE72640 658
MYCN BE2C GEO Homo sapiens GSE80151 41,547
MYCN SH-SY5Y ENA Homo sapiens ERP013415 399
MYCN SH-SY5Y OVERMYCN_24H ENA Homo sapiens ERP013415 132
MYCN COG-N-415 GEO Homo sapiens GSE138295 46,876
MYCN 22Rv1 intact GEO Homo sapiens GSE117304 16,133
MYCN 22Rv1 castrated GEO Homo sapiens GSE117304 9,890
MYCN SH-EP 2h GEO Homo sapiens GSE80151 866
MYCN SH-EP 6h GEO Homo sapiens GSE80151 1,862
MYCN SH-EP MYCNER_plusOHT GEO Homo sapiens GSE111905 37,307
MYCN SH-EP pRRL-MYCN GEO Homo sapiens GSE111905 34,928
MYCN SH-EP MYCNER_minOHT GEO Homo sapiens GSE111905 12,605
MYCN IMR-5 CD532 GEO Homo sapiens GSE78957 6,846
MYCN IMR-5 DMSO GEO Homo sapiens GSE78957 6,568
MYCN RH4 GEO Homo sapiens GSE83726 27,051
MYCN NGP GEO Homo sapiens GSE80151 17,858
MYCN SMS-KCN ENA Homo sapiens ERP013415 145
MYCN SMS-KCNR ENA Homo sapiens ERP013415 117
MYCN LNCaP DHT GEO Homo sapiens GSE117304 49,310
MYCN LNCaP EtOH GEO Homo sapiens GSE117304 37,763
MYCN Kelly res GEO Homo sapiens GSE115249 3,830
MYCN Kelly sensitive GEO Homo sapiens GSE115249 43,152
MYCN Kelly GEO Homo sapiens GSE94822 65,293
MYCN Kelly GEO Homo sapiens GSE80151 8,009
MYCN Kelly GEO Homo sapiens GSE94782 41,695
MYCN NB-1643 GEO Homo sapiens GSE138295 38,341
MYCN NB-1643 GEO Homo sapiens GSE94782 17,055
MYCN LA-N-5 GEO Homo sapiens GSE138295 57,439
MYCN MYCN-3 low GEO Homo sapiens GSE83317 20,175
MYCN MYCN-3 high GEO Homo sapiens GSE83317 1,026
MYCN prostate-cancer GEO Homo sapiens GSE117304 2,423
MYCN SHEP-21N DOX_24H GEO Homo sapiens GSE80151 18,406
MYCN SHEP-21N GEO Homo sapiens GSE80151 63,981
MYCN SHEP-21N DOX_0H GEO Homo sapiens GSE80151 22,500
MYCN SHEP-21N 24h GEO Homo sapiens GSE80151 21,240
MYCN SK-N-BE2-C GEO Homo sapiens GSE94822 34,500
MYCN SK-N-BE2-C GEO Homo sapiens GSE80151 41,038
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks