NFYA

Information NFYA

Description

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008]

Full Name

nuclear transcription factor Y subunit alpha

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
5
Biotypes
4
Peaks
63,662
Non-redundant peaks
42,474

TF Classification

Super Class
Other all-alpha-helical DNA-binding domains
Class
Heteromeric CCAAT-binding factors
Familly
Heteromeric CCAAT-binding factors
Sub Familly
None

Source TFClass

External IDs

NCBI Gene
4800
Official Gene Name
NFYA
JASPAR
MA0060
Ensembl
ENSG00000001167
UniProt
P23511
Genevisible
P23511
RefSeq
NM_002505
Aliases
CBF-A; CBF-B; HAP2; NF-YA
All peaks NFYA
Download BED file
Non redundant peaks NFYA
Download BED file
SEQUENCES NFYA
Download FASTA file
DOWNLOAD All ReMap
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Datasets Table for NFYA

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
NFYA Hep-G2 ENCODE Homo sapiens ENCSR124APT 23,736
NFYA K-562 GEO Homo sapiens GSE26439 26,335
NFYA K-562 ENCODE Homo sapiens ENCSR000EGR 4,798
NFYA GM12878 ENCODE Homo sapiens ENCSR000DNN 1,023
NFYA HeLa-S3 ENCODE Homo sapiens ENCSR000DNS 7,770
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks