NONO

Information NONO

Description

DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Important for the functional organization of GABAergic synapses. Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript (PubMed:26571461).Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. {ECO:0000250|UniProtKB:Q15233, ECO:0000269|PubMed:22966205, ECO:0000269|PubMed:26571461, ECO:0000269|PubMed:8355702, ECO:0000269|PubMed:9001221}.(Source UnitProtKB).

Full Name

non-POU-domain-containing, octamer binding protein

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
1
Biotypes
1
Peaks
739
Non-redundant peaks
739

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
53610
Official Gene Name
Nono
JASPAR
MGI
MGI:1855692
Ensembl
ENSMUSG00000031311
UniProt
Q99K48
Genevisible
Q99K48
RefSeq
Aliases
P54NRB
All peaks NONO
Download BED file
Non redundant peaks NONO
Download BED file
SEQUENCES NONO
Download FASTA file
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Datasets Table for NONO

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
NONO mESC GEO Mus musculus GSE73426 739
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks