NR5A1
Information NR5A1
- Description
Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity (By similarity). Transcription repressor of the Moloney leukemia virus long terminal repeat in undifferentiated murine embryonal carcinoma cells. Binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular phosphatidyl(3,4)bisphosphate, phosphatidyl(3,5)bisphosphate and phosphatidyl(3,4,5)triphosphate. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. {ECO:0000250, ECO:0000269|PubMed:17210646, ECO:0000269|PubMed:18988706}.(Source UnitProtKB).
- Full Name
nuclear receptor subfamily 5, group A, member 1
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 5
- Biotypes
- 2
- Peaks
- 11,383
- Non-redundant peaks
- 8,696
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 26423
- Official Gene Name
- Nr5a1
- JASPAR
- MGI
- MGI:1346833
- Ensembl
- ENSMUSG00000026751
- UniProt
- P33242
- Genevisible
- P33242
- RefSeq
- NM_139051
- Aliases
- Ad4BP; ELP; ELP-3; Ftz-F1; Ftzf1; SF-1; SF1; STF-1; adrenal 4-binding protein; steroidogenic factor 1
Datasets Table for NR5A1
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| NR5A1 | leydig-cells | GEO | Mus musculus | GSE106955 | 4,199 | |||
| NR5A1 | leydig-cells | cAMP | GEO | Mus musculus | GSE106955 | 2,795 | ||
| NR5A1 | striatal-cells | HdhQ111-Q111 | GEO | Mus musculus | GSE38000 | 102 | ||
| NR5A1 | striatal-cells | HdhQ7-Q7_HS | GEO | Mus musculus | GSE38000 | 3,223 | ||
| NR5A1 | striatal-cells | HdhQ111-Q111_HS | GEO | Mus musculus | GSE38000 | 1,064 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |