PAX5
Information PAX5
- Description
Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage (PubMed:9042861). Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes (PubMed:16546096). In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage (PubMed:9042861, PubMed:16546096). Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire (By similarity). {ECO:0000250|UniProtKB:Q02548, ECO:0000269|PubMed:16546096, ECO:0000269|PubMed:9042861}.(Source UnitProtKB).
- Full Name
paired box 5
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 11
- Biotypes
- 4
- Peaks
- 279,583
- Non-redundant peaks
- 108,407
TF Classification
- Familly
- Paired box factors
- Sub Familly
- Paired domain only
Source JASPAR
Datasets Table for PAX5
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| PAX5 | pro-B-cell | GEO | Mus musculus | GSE107239 | 7,002 | |||
| PAX5 | pro-B-cell | 26601 | GEO | Mus musculus | GSE84987 | 37,200 | ||
| PAX5 | pro-B-cell | GEO | Mus musculus | GSE84987 | 54,370 | |||
| PAX5 | pro-B-cell | 6h | GEO | Mus musculus | GSE107239 | 30,504 | ||
| PAX5 | bone-marrow | pro-B | GEO | Mus musculus | GSE38046 | 52,958 | ||
| PAX5 | bone-marrow | mature-B | GEO | Mus musculus | GSE38046 | 5,848 | ||
| PAX5 | lymph-node | GEO | Mus musculus | GSE84987 | 9,250 | |||
| PAX5 | pre-B-cell | GEO | Mus musculus | GSE126375 | 33,203 | |||
| PAX5 | pre-B-cell | GEO | Mus musculus | GSE113306 | 25,332 | |||
| PAX5 | pro-B-cell | GEO | Mus musculus | GSE126375 | 8,001 | |||
| PAX5 | pro-B-cell | 26598 | GEO | Mus musculus | GSE84987 | 15,915 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |