PCGF5
Information PCGF5
- Description
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:27136092, PubMed:28596365). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (By similarity). Plays a redundant role with PCGF3 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (PubMed:28596365). {ECO:0000250|UniProtKB:Q86SE9, ECO:0000269|PubMed:27136092, ECO:0000269|PubMed:28596365}.(Source UnitProtKB).
- Full Name
polycomb group ring finger 5
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 1
- Biotypes
- 1
- Peaks
- 1,641
- Non-redundant peaks
- 1,641
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 76073
- Official Gene Name
- Pcgf5
- JASPAR
- MGI
- MGI:1923505
- Ensembl
- ENSMUSG00000024805
- UniProt
- Q3UK78
- Genevisible
- Q3UK78
- RefSeq
- NM_029508
- Aliases
- 0610009F02Rik; 1110054A01Rik; 5830406C17Rik; 5830443C21Rik; 9530023M17Rik