PHF8

Information PHF8

Description

The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. The protein has an N-terminal PHD finger and a central Jumonji C domain. This gene is thought to function as a transcription activator. Defects in this gene are a cause of syndromic X-linked Siderius type intellectual disability (MRXSSD) and over-expression of this gene is associated with several forms of cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]

Full Name

PHD finger protein 8

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
6
Biotypes
5
Peaks
130,433
Non-redundant peaks
83,674

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
23133
Official Gene Name
PHF8
JASPAR
Ensembl
ENSG00000172943
UniProt
Q9UPP1
Genevisible
Q9UPP1
RefSeq
NM_001184896
Aliases
JHDM1F; KDM7B; KIAA1111; MRXSSD; ZNF422
All peaks PHF8
Download BED file
Non redundant peaks PHF8
Download BED file
SEQUENCES PHF8
Download FASTA file
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Datasets Table for PHF8

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
PHF8 HeLa GEO Homo sapiens GSE20303 2,918
PHF8 HeLa GEO Homo sapiens GSE22478 7,464
PHF8 Hep-G2 ENCODE Homo sapiens ENCSR604VAE 52,928
PHF8 WA01 ENCODE Homo sapiens ENCSR000ATK 28,000
PHF8 K-562 ENCODE Homo sapiens ENCSR000AQH 23,427
PHF8 A-549 ENCODE Homo sapiens ENCSR541AOQ 15,696
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks