REST

Information REST

Description

This gene was initially identified as a transcriptional repressor that represses neuronal genes in non-neuronal tissues. However, depending on the cellular context, this gene can act as either an oncogene or a tumor suppressor. The encoded protein is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regulator of neurogenesis. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2018]

Full Name

RE1 silencing transcription factor

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
47
Biotypes
26
Peaks
798,372
Non-redundant peaks
312,347

TF Classification

Super Class
Zinc-coordinating DNA-binding domains
Class
C2H2 zinc finger factors
Familly
Factors with multiple dispersed zinc fingers
Sub Familly
unclassified

Source TFClass

External IDs

NCBI Gene
5978
Official Gene Name
REST
JASPAR
MA0138
Ensembl
ENSG00000084093
UniProt
Q13127
Genevisible
Q13127
RefSeq
NM_001193508
Aliases
DFNA27; GINGF5; HGF5; NRSF; WT6; XBR

External links
All peaks REST
Download BED file
Non redundant peaks REST
Download BED file
SEQUENCES REST
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for REST

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
REST GP5D SIRAD21 GEO Homo sapiens GSE51234 2,790
REST GP5D GEO Homo sapiens GSE51234 3,096
REST K-562 GEO Homo sapiens GSE70482 8,833
REST NCI-H295R SF1 GEO Homo sapiens GSE49014 2,021
REST NCI-H295R GEO Homo sapiens GSE49014 2,108
REST LNCaP GEO Homo sapiens GSE119385 12,385
REST WA01 ENCODE Homo sapiens ENCSR663WAR 4,789
REST WA01 ENCODE Homo sapiens ENCSR000BHM 25,732
REST SK-N-SH ENCODE Homo sapiens ENCSR000BJJ 7,774
REST PANC-1 ENCODE Homo sapiens ENCSR000BJO 29,765
REST PANC-1 ENCODE Homo sapiens ENCSR000BPK 19,205
REST PANC-1 ENCODE Homo sapiens ENCSR000BUP 4,991
REST MCF-7 ENCODE Homo sapiens ENCSR000BSP 14,943
REST K-562 ENCODE Homo sapiens ENCSR137ZMQ 53,370
REST K-562 ENCODE Homo sapiens ENCSR000BMW 53,917
REST K-562 ENCODE Homo sapiens ENCSR000ATM 6,787
REST HL-60 ENCODE Homo sapiens ENCSR000BTF 11,159
REST Hep-G2 ENCODE Homo sapiens ENCSR000BOT 27,546
REST Hep-G2 ENCODE Homo sapiens ENCSR000BJL 5,378
REST GM23338 ENCODE Homo sapiens ENCSR871KYB 8,109
REST A-549 ENCODE Homo sapiens ENCSR000BQP 48,561
REST A-549 ENCODE Homo sapiens ENCSR892DRK 11,833
REST PFSK1 ENCODE Homo sapiens ENCSR000BOX 20,884
REST PFSK1 ENCODE Homo sapiens ENCSR000BJP 7,913
REST neural ENCODE Homo sapiens ENCSR000BTV 57,195
REST liver ENCODE Homo sapiens ENCSR893QWP 27,753
REST liver ENCODE Homo sapiens ENCSR867WPH 41,876
REST Ishikawa ENCODE Homo sapiens ENCSR000BUU 13,383
REST hepatocyte ENA Homo sapiens ERP000395 1,186
REST HEK293 ENCODE Homo sapiens ENCSR896UBV 27,174
REST GM12878 ENCODE Homo sapiens ENCSR000BGF 8,676
REST GM12878 ENCODE Homo sapiens ENCSR000BQS 20,698
REST CD4 GEO Homo sapiens GSE49570 15,756
REST hiPSC IA12 GEO Homo sapiens GSE106870 12,504
REST hiPSC IB12 GEO Homo sapiens GSE106870 16,969
REST hiPSC IID12 GEO Homo sapiens GSE106870 10,524
REST hiPSC IIA11 GEO Homo sapiens GSE106870 6,874
REST colorectal-cancer CRC121_dissociated GEO Homo sapiens GSE112555 5,815
REST colorectal-cancer shCDH1 GEO Homo sapiens GSE112555 29,595
REST colorectal-cancer shCTRL_dissociated GEO Homo sapiens GSE112555 8,415
REST colorectal-cancer shCTRL_intact GEO Homo sapiens GSE112555 15,574
REST colorectal-cancer CRC121_intact GEO Homo sapiens GSE112555 16,224
REST metastatic-neuroblastoma CHLA90 GEO Homo sapiens GSE100148 2,949
REST metastatic-neuroblastoma SKNMM GEO Homo sapiens GSE100148 1,118
REST HeLa-S3 ENCODE Homo sapiens ENCSR000BMN 23,139
REST HCT-116 ENCODE Homo sapiens ENCSR000BVI 4,424
REST hippocampus GEO Homo sapiens GSE144226 36,662
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks