SMAD2

Information SMAD2

Description

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

Full Name

SMAD family member 2

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
7
Biotypes
4
Peaks
24,088
Non-redundant peaks
18,240

TF Classification

Super Class
beta-Hairpin exposed by an alpha/beta-scaffold
Class
SMAD/NF-1 DNA-binding domain factors
Familly
SMAD factors
Sub Familly
Regulatory Smads (R-Smad)

Source TFClass

External IDs

NCBI Gene
4087
Official Gene Name
SMAD2
JASPAR
MA0513
Ensembl
ENSG00000175387
UniProt
Q15796
Genevisible
Q15796
RefSeq
NM_001003652
Aliases
JV18; JV18-1; MADH2; MADR2; hMAD-2; hSMAD2
All peaks SMAD2
Download BED file
Non redundant peaks SMAD2
Download BED file
SEQUENCES SMAD2
Download FASTA file
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Datasets Table for SMAD2

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
SMAD2 K-562 ENCODE Homo sapiens ENCSR189PYJ 392
SMAD2 hESC GEO Homo sapiens GSE29422 2,943
SMAD2 hESC activinA_15h GEO Homo sapiens GSE99202 4,379
SMAD2 hESC YAP-_activinA_15h GEO Homo sapiens GSE99202 7,287
SMAD2 endoderm GEO Homo sapiens GSE29422 7,541
SMAD2 HASMC PBS GEO Homo sapiens GSE112326 472
SMAD2 HASMC TGFb GEO Homo sapiens GSE112326 1,074
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks