SMAD3

Information SMAD3

Description

The SMAD family of proteins are a group of intracellular signal transducer proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. The SMAD3 protein functions in the transforming growth factor-beta signaling pathway, and transmits signals from the cell surface to the nucleus, regulating gene activity and cell proliferation. It also functions as a tumor suppressor. Mutations in this gene are associated with aneurysms-osteoarthritis syndrome and Loeys-Dietz Syndrome 3. [provided by RefSeq, Nov 2019]

Full Name

SMAD family member 3

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
32
Biotypes
15
Peaks
675,766
Non-redundant peaks
282,068

TF Classification

Super Class
beta-Hairpin exposed by an alpha/beta-scaffold
Class
SMAD/NF-1 DNA-binding domain factors
Familly
SMAD factors
Sub Familly
Regulatory Smads (R-Smad)

Source TFClass

External IDs

NCBI Gene
4088
Official Gene Name
SMAD3
JASPAR
MA0795
Ensembl
ENSG00000166949
UniProt
P84022
Genevisible
P84022
RefSeq
NM_001145102
Aliases
HSPC193; HsT17436; JV15-2; LDS1C; LDS3; MADH3

External links
All peaks SMAD3
Download BED file
Non redundant peaks SMAD3
Download BED file
SEQUENCES SMAD3
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for SMAD3

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
SMAD3 LX2 CALCIPOTRIOL_TGFB1 GEO Homo sapiens GSE38103 29,623
SMAD3 LX2 TGFB1 GEO Homo sapiens GSE38103 1,235
SMAD3 H69 5Veh GEO Homo sapiens GSE145250 32,292
SMAD3 H69 5TGF GEO Homo sapiens GSE145250 30,885
SMAD3 H69 4TGF GEO Homo sapiens GSE145250 43,114
SMAD3 H69 4Veh GEO Homo sapiens GSE145250 29,616
SMAD3 PC-3 hypoxia GEO Homo sapiens GSE106305 58,079
SMAD3 NCI-H441 GEO Homo sapiens GSE51509 49,513
SMAD3 NCI-H441 SIITTF1 GEO Homo sapiens GSE51509 54,335
SMAD3 BG03 DIFF_2H GEO Homo sapiens GSE36578 8,877
SMAD3 BG03 GEO Homo sapiens GSE36578 34,287
SMAD3 BG03 DIFF_48H GEO Homo sapiens GSE36578 8,318
SMAD3 BG03 GEO Homo sapiens GSE21614 17,097
SMAD3 BG03 DIFF_0H GEO Homo sapiens GSE36578 2,615
SMAD3 HCC1954 GEO Homo sapiens GSE104760 61,372
SMAD3 HCC1954 TGFb GEO Homo sapiens GSE104760 64,685
SMAD3 Hep-G2 ENCODE Homo sapiens ENCSR005GZH 73,875
SMAD3 K-562 ENCODE Homo sapiens ENCSR376XAV 3,955
SMAD3 MDA-MB-231 TGF-beta GEO Homo sapiens GSE92443 5,119
SMAD3 MDA-MB-231 GEO Homo sapiens GSE92443 170
SMAD3 SUM159PT GEO Homo sapiens GSE130364 23,414
SMAD3 hESC GEO Homo sapiens GSE75297 160
SMAD3 hESC GEO Homo sapiens GSE29422 7,031
SMAD3 hESC DIFF_D1 GEO Homo sapiens GSE75297 277
SMAD3 hESC DIFF_D0 GEO Homo sapiens GSE75297 89
SMAD3 hESC DIFF_D2 GEO Homo sapiens GSE75297 103
SMAD3 endoderm GEO Homo sapiens GSE29422 4,526
SMAD3 HMLE GEO Homo sapiens GSE104760 879
SMAD3 HMLE Doxycicline_TGFb GEO Homo sapiens GSE104760 14,891
SMAD3 HMLE TGFb GEO Homo sapiens GSE104760 4,633
SMAD3 breast-cancer triple-negative GEO Homo sapiens GSE130364 10,513
SMAD3 HCASMC GEO Homo sapiens GSE115317 188
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks