SOX10
Information SOX10
- Description
Transcription factor that plays a central role in developing and mature glia (PubMed:24204311, PubMed:27532821). Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (PubMed:24204311, PubMed:27532821). Once induced, MYRF cooperates with SOX10 to implement the myelination program (PubMed:24204311). Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity). Transcriptional activator of MBP, via binding to the gene promoter (By similarity). {ECO:0000250|UniProtKB:O55170, ECO:0000250|UniProtKB:P56693, ECO:0000269|PubMed:24204311, ECO:0000269|PubMed:27532821}.(Source UnitProtKB).
- Full Name
SRY (sex determining region Y)-box 10
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 1
- Biotypes
- 1
- Peaks
- 6,028
- Non-redundant peaks
- 6,028
TF Classification
- Familly
- High-mobility group (HMG) domain factors
- Sub Familly
- SOX-related factors
Source JASPAR
Datasets Table for SOX10
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| SOX10 | embryonic-skin | GEO | Mus musculus | GSE69949 | 6,028 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |