SPIB
Information SPIB
- Description
Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. Required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation. {ECO:0000269|PubMed:10229183, ECO:0000269|PubMed:11313289, ECO:0000269|PubMed:11672537, ECO:0000269|PubMed:11980719, ECO:0000269|PubMed:12431391, ECO:0000269|PubMed:8691135, ECO:0000269|PubMed:9384589}.(Source UnitProtKB).
- Full Name
Spi-B transcription factor (Spi-1/PU.1 related)
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 1
- Biotypes
- 1
- Peaks
- 3,650
- Non-redundant peaks
- 3,650
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 272382
- Official Gene Name
- Spib
- JASPAR
- MGI
- MGI:892986
- Ensembl
- ENSMUSG00000008193
- UniProt
- O35906
- Genevisible
- O35906
- RefSeq
- Aliases
- Spi-B