SUPT16
Information SUPT16
- Description
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). {ECO:0000250|UniProtKB:Q9Y5B9, ECO:0000269|PubMed:23364797}.
- Full Name
SPT16, facilitates chromatin remodeling subunit
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 3
- Biotypes
- 1
- Peaks
- 100,062
- Non-redundant peaks
- 92,360
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 114741
- Official Gene Name
- Supt16
- JASPAR
- MGI
- MGI:1890948
- Ensembl
- ENSMUSG00000035726
- UniProt
- Q920B9
- Genevisible
- Q920B9
- RefSeq
- NM_033618
- Aliases
- Cdc68; Fact140; Spt16; Supt16h
Datasets Table for SUPT16
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| SUPT16 | mESC | GEO | Mus musculus | GSE90906 | 67,696 | |||
| SUPT16 | mESC | d0 | GEO | Mus musculus | GSE117155 | 6,978 | ||
| SUPT16 | mESC | d5 | GEO | Mus musculus | GSE117155 | 25,388 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |