TAF1

Information TAF1

Description

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N- and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. Mutations in this gene result in Dystonia 3, torsion, X-linked, a dystonia-parkinsonism disorder. Alternative splicing of this gene results in multiple transcript variants. This gene is part of a complex transcription unit (TAF1/DYT3), wherein some transcript variants share exons with TAF1 as well as additional downstream DYT3 exons. [provided by RefSeq, Oct 2013]

Full Name

TATA-box binding protein associated factor 1

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
15
Biotypes
14
Peaks
326,914
Non-redundant peaks
133,604

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
6872
Official Gene Name
TAF1
JASPAR
Ensembl
ENSG00000147133
UniProt
P21675
Genevisible
P21675
RefSeq
NM_001286074
Aliases
BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4; MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A; TAFII-250; TAFII250; XDP
All peaks TAF1
Download BED file
Non redundant peaks TAF1
Download BED file
SEQUENCES TAF1
Download FASTA file
DOWNLOAD All ReMap
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Datasets Table for TAF1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
TAF1 Hep-G2 ENCODE Homo sapiens ENCSR918OKK 35,837
TAF1 WA01 ENCODE Homo sapiens ENCSR000BHO 37,454
TAF1 SK-N-SH ENCODE Homo sapiens ENCSR000BQF 41,268
TAF1 MCF-7 ENCODE Homo sapiens ENCSR000AHF 7,387
TAF1 K-562 ENCODE Homo sapiens ENCSR000BKS 29,810
TAF1 Hep-G2 ENCODE Homo sapiens ENCSR000BJN 17,809
TAF1 A-549 ENCODE Homo sapiens ENCSR000BPF 14,042
TAF1 PFSK1 ENCODE Homo sapiens ENCSR000BQN 10,236
TAF1 neural ENCODE Homo sapiens ENCSR000BTX 22,117
TAF1 liver ENCODE Homo sapiens ENCSR016BMM 13,633
TAF1 Ishikawa ENCODE Homo sapiens ENCSR000BTO 21,940
TAF1 GM12892 ENCODE Homo sapiens ENCSR000BIB 10,995
TAF1 GM12891 ENCODE Homo sapiens ENCSR000BIM 11,337
TAF1 GM12878 ENCODE Homo sapiens ENCSR000BGS 28,521
TAF1 HeLa-S3 ENCODE Homo sapiens ENCSR000BHT 24,528
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks