TCF4
Information TCF4
- Description
This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs endothelial corneal dystrophy. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq, Jul 2016]
- Full Name
transcription factor 4
Source NCBI
- Species
Homo sapiens [tax_id: 9606]
- Genome
hg38
ReMap Statistics
- Datasets
- 6
- Biotypes
- 5
- Peaks
- 121,312
- Non-redundant peaks
- 89,849
TF Classification
- Super Class
- Basic domains
- Class
- Basic helix-loop-helix factors (bHLH)
- Familly
- E2A-related factors
- Sub Familly
- None
Source TFClass
External IDs
- NCBI Gene
- 6925
- Official Gene Name
- TCF4
- JASPAR
- MA0830
- Ensembl
- ENSG00000196628
- UniProt
- P15884
- Genevisible
- P15884
- RefSeq
- NM_001083962
- Aliases
- E2-2; FECD3; ITF-2; ITF2; PTHS; SEF-2; SEF2; SEF2-1; SEF2-1A; SEF2-1B; SEF2-1D; TCF-4; bHLHb19
Datasets Table for TCF4
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| TCF4 | SH-SY5Y | GEO | Homo sapiens | GSE96915 | 10,911 | |||
| TCF4 | LS180 | GEO | Homo sapiens | GSE31939 | 8,271 | |||
| TCF4 | LS180 | 125 | GEO | Homo sapiens | GSE31939 | 9,537 | ||
| TCF4 | SW1783 | GEO | Homo sapiens | GSE92483 | 1,025 | |||
| TCF4 | GEN2-2 | GEO | Homo sapiens | GSE76147 | 54,628 | |||
| TCF4 | CAL-1 | GEO | Homo sapiens | GSE76147 | 36,940 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |