TCF7

Information TCF7

Description

This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling. [provided by RefSeq, Oct 2016]

Full Name

transcription factor 7

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
6
Biotypes
4
Peaks
62,149
Non-redundant peaks
55,190

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
6932
Official Gene Name
TCF7
JASPAR
Ensembl
ENSG00000081059
UniProt
P36402
Genevisible
P36402
RefSeq
NM_001134851
Aliases
TCF-1
All peaks TCF7
Download BED file
Non redundant peaks TCF7
Download BED file
SEQUENCES TCF7
Download FASTA file
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Datasets Table for TCF7

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
TCF7 K-562 ENCODE Homo sapiens ENCSR863KUB 7,611
TCF7 Hep-G2 ENCODE Homo sapiens ENCSR444LIN 22,872
TCF7 GM12878 ENCODE Homo sapiens ENCSR501DKS 10,895
TCF7 breast-organoid GEO Homo sapiens GSE113909 4,418
TCF7 breast-organoid BRCA1-mut GEO Homo sapiens GSE113909 5,842
TCF7 breast-organoid BRCA2-mut GEO Homo sapiens GSE113909 10,511
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks