TCF7L2
Information TCF7L2
- Description
This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]
- Full Name
transcription factor 7 like 2
Source NCBI
- Species
Homo sapiens [tax_id: 9606]
- Genome
hg38
ReMap Statistics
- Datasets
- 18
- Biotypes
- 11
- Peaks
- 249,332
- Non-redundant peaks
- 132,076
TF Classification
- Super Class
- Other all-alpha-helical DNA-binding domains
- Class
- High-mobility group (HMG) domain factors
- Familly
- TCF-7-related factors
- Sub Familly
- None
Source TFClass
External IDs
- NCBI Gene
- 6934
- Official Gene Name
- TCF7L2
- JASPAR
- MA0830
- Ensembl
- ENSG00000148737
- UniProt
- Q9NQB0
- Genevisible
- Q9NQB0
- RefSeq
- NM_001146274
- Aliases
- TCF-4; TCF4
Datasets Table for TCF7L2
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| TCF7L2 | CD34 | PROG_BIO | GEO | Homo sapiens | GSE29194 | 12,541 | ||
| TCF7L2 | Hep-G2 | ENCODE | Homo sapiens | ENCSR346BOD | 28,183 | |||
| TCF7L2 | LNCaP | GEO | Homo sapiens | GSE51621 | 27,865 | |||
| TCF7L2 | PANC-1 | ENCODE | Homo sapiens | ENCSR000EXL | 25,879 | |||
| TCF7L2 | MCF-7 | ENCODE | Homo sapiens | ENCSR000EWT | 9,286 | |||
| TCF7L2 | K-562 | ENCODE | Homo sapiens | ENCSR888XZK | 4,491 | |||
| TCF7L2 | Hep-G2 | ENCODE | Homo sapiens | ENCSR000EVQ | 2,120 | |||
| TCF7L2 | HEK293 | ENCODE | Homo sapiens | ENCSR000EUY | 9,544 | |||
| TCF7L2 | MDA-MB-453 | DHT | GEO | Homo sapiens | GSE45201 | 342 | ||
| TCF7L2 | MDA-MB-453 | GEO | Homo sapiens | GSE45201 | 19,569 | |||
| TCF7L2 | HeLa-S3 | ENCODE | Homo sapiens | ENCSR000EVE | 20,372 | |||
| TCF7L2 | HeLa-S3 | ENCODE | Homo sapiens | ENCSR000EVF | 2,950 | |||
| TCF7L2 | HCT-116 | ENCODE | Homo sapiens | ENCSR000EUV | 51,248 | |||
| TCF7L2 | HCT-116 | C16 | GEO | Homo sapiens | GSE127960 | 6,758 | ||
| TCF7L2 | HCT-116 | sc2 | GEO | Homo sapiens | GSE127960 | 10,265 | ||
| TCF7L2 | HCT-116 | WT | GEO | Homo sapiens | GSE127960 | 5,660 | ||
| TCF7L2 | HCT-116 | C18 | GEO | Homo sapiens | GSE127960 | 6,120 | ||
| TCF7L2 | hepatocellular-carcinoma-cell | 420 | GEO | Homo sapiens | GSE138781 | 6,139 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |