XBP1

Information XBP1

Description

This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]

Full Name

X-box binding protein 1

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
6
Biotypes
4
Peaks
86,769
Non-redundant peaks
56,384

TF Classification

Super Class
Basic domains
Class
Basic leucine zipper factors (bZIP)
Familly
XBP-1-related factors
Sub Familly
None

Source TFClass

External IDs

NCBI Gene
7494
Official Gene Name
XBP1
JASPAR
MA0844
Ensembl
ENSG00000100219
UniProt
P17861
Genevisible
P17861
RefSeq
NM_001079539
Aliases
TREB-5; TREB5; XBP-1; XBP2
All peaks XBP1
Download BED file
Non redundant peaks XBP1
Download BED file
SEQUENCES XBP1
Download FASTA file
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Datasets Table for XBP1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
XBP1 HS578T HYPO_GLUDEP GEO Homo sapiens GSE49952 3,929
XBP1 T-47D HYPO_GLUDEP GEO Homo sapiens GSE49952 85
XBP1 LNCaP px330 GEO Homo sapiens GSE121880 22,791
XBP1 LNCaP Tg GEO Homo sapiens GSE121880 49,719
XBP1 LNCaP R1881 GEO Homo sapiens GSE121880 9,576
XBP1 plasmablast GEO Homo sapiens GSE142493 669
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks