AGO1
Information AGO1
- Description
This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon. [provided by RefSeq, Nov 2015]
- Full Name
argonaute RISC component 1
Source NCBI
- Species
Homo sapiens [tax_id: 9606]
- Genome
hg38
ReMap Statistics
- Datasets
- 4
- Biotypes
- 2
- Peaks
- 149,218
- Non-redundant peaks
- 77,244
TF Classification
- Super Class
- NA
- Class
- NA
- Familly
- NA
- Sub Familly
- NA
Source TFClass
External IDs
- NCBI Gene
- 26523
- Official Gene Name
- AGO1
- JASPAR
- Ensembl
- ENSG00000092847
- UniProt
- Q9UL18
- Genevisible
- Q9UL18
- RefSeq
- NM_001317122
- Aliases
- EIF2C; EIF2C1; GERP95; Q99; hAGO1; hAgo1
Datasets Table for AGO1
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| AGO1 | Hep-G2 | GEO | Homo sapiens | GSE120104 | 51,141 | |||
| AGO1 | K-562 | GEO | Homo sapiens | GSE120104 | 16,182 | |||
| AGO1 | K-562 | ENCODE | Homo sapiens | ENCSR641BSL | 22,730 | |||
| AGO1 | Hep-G2 | ENCODE | Homo sapiens | ENCSR555ZMV | 59,165 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |